V1377
Vinblastine sulfate salt
≥97% (HPLC), powder, plant alkaloid
Synonym(s):
VLB, Vincaleukoblastine sulfate salt
About This Item
Recommended Products
product name
Vinblastine sulfate salt, ≥97% (HPLC)
Quality Level
Assay
≥97% (HPLC)
form
(powder or amorphous or crystalline powder)
color
white to light yellow
mp
267 °C (dec.) (lit.)
absorption
14 at 270 nm in 0.1 M phosphate buffer at 1 mM
16.2 at 259 nm in ethanol at 1 mM
53.7 at 214 nm in ethanol at 1 mM
antibiotic activity spectrum
neoplastics
Mode of action
DNA synthesis | interferes
originator
Eli Lilly
storage temp.
2-8°C
SMILES string
OS(O)(=O)=O.[H][C@@]12CN(CCc3c([nH]c4ccccc34)[C@@](C1)(C(=O)OC)c5cc6c(cc5OC)N(C)[C@@]7([H])[C@](O)([C@H](OC(C)=O)[C@]8(CC)C=CCN9CC[C@]67[C@]89[H])C(=O)OC)C[C@](O)(CC)C2
InChI
1S/C46H58N4O9.H2O4S/c1-8-42(54)23-28-24-45(40(52)57-6,36-30(15-19-49(25-28)26-42)29-13-10-11-14-33(29)47-36)32-21-31-34(22-35(32)56-5)48(4)38-44(31)17-20-50-18-12-16-43(9-2,37(44)50)39(59-27(3)51)46(38,55)41(53)58-7;1-5(2,3)4/h10-14,16,21-22,28,37-39,47,54-55H,8-9,15,17-20,23-26H2,1-7H3;(H2,1,2,3,4)/t28-,37-,38+,39+,42-,43+,44+,45-,46-;/m0./s1
InChI key
KDQAABAKXDWYSZ-PNYVAJAMSA-N
Gene Information
human ... TBCC(6903) , TUBA1A(7846) , TUBA1B(10376) , TUBA1C(84790) , TUBA3C(7278) , TUBA3E(112714) , TUBA4A(7277) , TUBB(203068) , TUBB1(81027) , TUBB2A(7280) , TUBB2B(347733) , TUBB3(10381) , TUBB4A(10382) , TUBB4B(10383) , TUBB6(84617) , TUBB8(347688)
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Application
- as a microtubule depolymerizing drug for the synchronization of human cell lines in G2/M phase
- as a multidrug resistance screening substrate in human colon cancer cell line (HCT116) cell line
- as an antimicrotubule agent in sub perineural glia of Drosophila brain
Biochem/physiol Actions
Features and Benefits
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral - Muta. 2 - Repr. 2
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Certificates of Analysis (COA)
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