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T5662

Sigma-Aldrich

Toxic shock syndrome toxin-1 from Staphylococcus aureus

Synonym(s):

Staphylococcal Enterotoxin F, TSST-1

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About This Item

MDL number:
MFCD00132435
UNSPSC Code:
12352202
NACRES:
NA.77

composition

Contains ~50% protein (Lowry); balance primarily sodium chloride and sodium phosphate buffer.

Quality Level

200

availability

not available in USA

solubility

H2O: soluble 0.50-0.60 mg/mL, clear to slightly hazy, colorless to faintly yellow

storage temp.

−20°C

Application

TSST-1 has been used for superantigen stimulation in T cells. Furthermore, studies have reported that TSST-1 can induce TNF-α secretion in peripheral blood mononuclear cells (PBMCs)4,5.

Biochem/physiol Actions

Superantigen for T-lymphocytes.

Preparation Note

Toxic shock syndrome toxin-1 (TSST-1) is soluble in water at 0.50 - 0.60 mg/ml and yields a clear to slightly hazy, colorless to faint yellow solution.

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H300 + H310 + H330

Hazard Classifications

Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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L Blanco et al.
Infection and immunity, 58(9), 3020-3028 (1990-09-01)
Toxic shock syndrome toxin 1 (TSST-1), a 22-kilodalton protein made by strains of Staphylococcus aureus harboring the chromosomal toxin gene, may elicit toxic shock syndrome in humans. In vitro, TSST-1 induces T cells to proliferate and macrophages to secrete interleukin-1.
M Ramírez et al.
International immunology, 11(9), 1479-1489 (1999-08-28)
The superantigen toxic shock syndrome toxin (TSST)-1 can induce tumor necrosis factor (TNF)-alpha expression in T cells and monocytes, through different signaling pathways. We have stimulated peripheral blood mononuclear cells with TSST-1 and found that the major cell producers of
M Buxadé et al.
Immunology, 102(4), 416-425 (2001-05-01)
Tumour necrosis factor-alpha (TNF-alpha) is a proinflammatory cytokine produced by several cell types, including T cells upon antigen stimulation. Its production is crucial for the development of an early defence against many pathogens, but its beneficial effects are dependent on
Khojasteh V Javid et al.
Iranian journal of microbiology, 3(4), 170-176 (2012-04-25)
The aim of study was to develop a rapid assay, dye labelled monoclonal antibody assay (DLMAA), using non-radioactive organic synthetic dyes for identification of Toxic Shock Syndrome Toxin-1 (TSST-1) producing strains of Staphylococcus aureus. The assay protocol required only two
P Marrack et al.
Science (New York, N.Y.), 248(4956), 705-711 (1990-05-11)
Staphylococcal enterotoxins and a group of related proteins made by Streptococci cause food poisoning and shock in man and animals. These proteins share an ability to bind to human and mouse major histocompatibility complex proteins. The complex ligand so formed
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