T104

Tropisetron monohydrochloride

solid, ≥98% (HPLC)

• Synonym(s): 1H-Indole-3-carboxylic acid (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester monohydrochloride, 3-Tropanylindole-3-carboxylate monohydrochloride, ICS-205,930, Navoban
• Empirical Formula (Hill Notation): C₁₇H₂₀N₂O₂ · HCl
• CAS Number: 105826-92-4
• Molecular Weight: 320.81
• MDL number: MFCD00210221
• UNSPSC Code: 12352200
• PubChem Substance ID: 24278133
• NACRES: NA.77

Properties

• Assay: ≥98% (HPLC)
• form: solid
• solubility: H₂O: >10 mg/mL
• originator: Novartis
• storage temp.: 2-8°C
• SMILES string: Cl[H].CN1C2CCC1CC(C2)OC(=O)c3c[nH]c4ccccc34
• InChI: 1S/C17H20N2O2.ClH/c1-19-11-6-7-12(19)9-13(8-11)21-17(20)15-10-18-16-5-3-2-4-14(15)16;/h2-5,10-13,18H,6-9H2,1H3;1H
• InChI key: XIEGSJAEZIGKSA-UHFFFAOYSA-N
• Gene Information: human ... CHRNA3(1136) , CHRNA4(1137) , CHRNB2(1141) , CHRNB4(1143) , HTR3A(3359) , HTR3B(9177) , HTR3C(170572) , HTR3D(200909) , HTR3E(285242) ; rat ... Chrna7(25302) , Drd2(24318) , Htr1a(24473) , Htr3a(79246)

Description

Application

Tropisetron monohydrochloride was used as a standard to determine the tropisetron in human plasma using HPLC method with UV detection.

Biochem/physiol Actions

3-Tropanylindole-3-carboxylate hydrochloride is a selective 5-HT₃ serotonin receptor antagonist.

Selective 5-HT₃ serotonin receptor antagonist.

Tropisetron a selective serotonin 5-HT₃ receptor antagonist is used mainly as an antiemetic to treat nausea and vomiting following chemotherapy . In the treatment of fibromyalgia syndrome (FMS) tropisetron reduced not only pain perception but also had a favourable effect on cardiac dysfunction during treatment.

Features and Benefits

This compound is featured on the Acetylcholine Receptors (Nicotinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves