SML3942
DUB-IN-2
≥98% (HPLC)
Synonym(s):
9-Ethoxyimino-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile, DUB Inhibitor 2, DUBs Inhibitor 2, DUBs-IN-2, Deubiquitinase Inhibitor 2
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About This Item
Empirical Formula (Hill Notation):
C15H9N5O
CAS Number:
Molecular Weight:
275.26
UNSPSC Code:
12352200
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Quality Level
Assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
Biochem/physiol Actions
Potent and selective ubiquitin specific peptidase USP8 deubiquitinase (DUB) inhibitor.
DUBs-IN-2 is a potent and selective ubiquitin specific peptidase USP8 deubiquitinase (DUB) inhibitor (IC50 = 280 nM/USP8, >100 µM/USP7). DUBs-IN-2 inhibits the proliferation of gastric cancer (GC) cell NCI-N87 in cultures (IC50 = 480 nM post 3-day incubation) and NCI-N87-derived tumor growth in mice in vivo (2 mg/kg/d 5x per wk) by promoting HER-2 degradation.
DUBs-IN-2 is a potent and selective ubiquitin specific peptidase USP8 deubiquitinase (DUB) inhibitor (IC50 = 280 nM/USP8, >100 µM/USP7). DUBs-IN-2 inhibits the proliferation of gastric cancer (GC) cell NCI-N87 in cultures (IC50 = 480 nM post 3-day incubation) and NCI-N87-derived tumor growth in mice in vivo (2 mg/kg/d 5x per wk) by promoting HER-2 degradation.
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