SBR00057

Retapamulin

≥98% (HPLC)

• Empirical Formula (Hill Notation): C₃₀H₄₇NO₄S
• CAS Number: 224452-66-8
• Molecular Weight: 517.76
• MDL number: MFCD11045316

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• antibiotic activity spectrum: Gram-positive bacteria
• Mode of action: protein synthesis | interferes
• storage temp.: −20°C
• InChI: 1S/C30H47NO4S/c1-7-28(4)16-24(35-25(33)17-36-22-14-20-8-9-21(15-22)31(20)6)29(5)18(2)10-12-30(19(3)27(28)34)13-11-23(32)26(29)30/h7,18-22,24,26-27,34H,1,8-17H2,2-6H3/t18-,19+,20-,21+,22?,24-,26+,27+,28-,29+,30+/m1/s1
• InChI key: STZYTFJPGGDRJD-FJJJPKKESA-N

Description

General description

Retapamulin (RET) is a semi-synthetic antibiotic ointment, and pleuromutilin derivative compound. The primary structural difference between pleuromutilin and retapamulin is in the C-14 side chain.

Biochem/physiol Actions

Retapamulin is a potent antibacterial agent against Gram-positive bacteria, especially against Staphylococcus aureus and S. pyogenes. It displays synergistic effects against Enterococcus faecalis in combination with streptogramin (MLS). RET initiates ribosomal arrests at the start codon and enables genes to use alternative translational sites in E. coli.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable