SAB4702063

Monoclonal Anti-DLL4 purified low endotoxin produced in mouse

• Synonym(s): AOS6, Delta like ligand 4, canonical Notch ligand 4
• UNSPSC Code: 12352203

Properties

• conjugate: unconjugated
• Quality Level: 100
• antibody product type: primary antibodies
• clone: MHD4-46, monoclonal
• form: buffered aqueous solution
• species reactivity: human
• concentration: 1 mg/ml
• technique(s): FUNC: suitable; flow cytometry: suitable
• isotype: IgG1κ
• UniProt accession no.: Q9NR61
• storage temp.: 2-8°C
• target post-translational modification: unmodified
• Gene Information: human ... DLL4(54567)

Description

General description

DLL4 (Delta-like 4) is one of five ligands of Notch receptors. It interacts with Notch1 and Notch4. DLL4 is up-regulated at sites of physiologic and pathologic angiogenesis, whereas its expression is low in most adult normal tissues. It is also highly expressed in human clear-cell renal carcinomas, bladder cancers, and breast cancers. Blocking the DLL4-Notch interaction seems to be a promissing therapeutic approach.

Specificity

The mouse monoclonal antibody MHD4-46 recognizes the extracellular domain of DLL4 (Delta-like ligand 4), a type I transmembrane protein which plays an important role in vascular development.

Immunogen

recombinant soluble human DLL4

Physical form

Phosphate buffered saline (PBS), pH 7.4

Preparation Note

Purified by protein-A affinity chromatography.

Storage and Stability

Store at 2-8°C. Do not freeze.

Other Notes

The antibody solution should be gently mixed before use.

Safety Information

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 1