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Key Documents

SAB2501381

Sigma-Aldrich

Anti-Cd28 antibody produced in goat

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-CH29-189K17.3, Anti-OTTMUSP00000002157, CD28 antigen, T-cell-specific surface glycoprotein CD28

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

goat

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

mouse, pig

technique(s)

indirect ELISA: suitable
western blot: suitable

UniProt accession no.

P31041

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

mouse ... Cd28(12487)

General description

Cluster of differentiation 28 (CD28) antigen is a co-stimulatory receptor expressed in naive T-cells. It contains a short cytoplasmic tail and two proline-rich motifs.

Immunogen

Peptide with sequence KEKHLCHTQSSPK, from the internal region of the protein sequence according to NP_031668.3

Biochem/physiol Actions

Cluster of differentiation 28 (CD28) antigen has a role in T-cell activation, proliferation, survival and function. It modulates thymic development, peripheral homeostasis and the suppressive functions of regulatory T cells. CD28 has a role in signal transduction and is involved in activating many adaptor proteins.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Supplied at 0.5 mg/mL in 20mM Tris (pH 7.3) and 150mM NaCl with 0.02% sodium azide and 0.5% bovine serum albumin.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Defects in regulatory T cells due to CD28 deficiency induce a qualitative change of allogeneic immune response in chronic graft-versus-host disease.
Akieda Y
Journal of Immunology (2015)
Interrupting CD28 costimulation before antigen rechallenge affects CD8(+) T-cell expansion and effector functions during secondary response in mice.
Frohlich M
European Journal of Immunology (2016)
CD28 Deficiency Enhances Type I IFN Production by Murine Plasmacytoid Dendritic Cells.
Macal M
Journal of Immunology (2016)
CD28 Promotes Plasma Cell Survival, Sustained Antibody Responses, and BLIMP-1 Upregulation through Its Distal PYAP Proline Motif.
Rozanski CH
Journal of Immunology (2015)
Nicole A Braun et al.
American journal of respiratory and critical care medicine, 190(5), 560-571 (2014-07-30)
Effective therapeutic interventions for chronic, idiopathic lung diseases remain elusive. Normalized T-cell function is an important contributor to spontaneous resolution of pulmonary sarcoidosis. Up-regulation of inhibitor receptors, such as programmed death-1 (PD-1) and its ligand, PD-L1, are important inhibitors of
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