PZ0111

PD-407824

≥98% (HPLC)

• Synonym(s): 9-Hydroxy-4-phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione
• Empirical Formula (Hill Notation): C₂₀H₁₂N₂O₃
• CAS Number: 622864-54-4
• Molecular Weight: 328.32
• MDL number: MFCD09753286
• UNSPSC Code: 12352200
• PubChem Substance ID: 329823703
• NACRES: NA.77

Properties

• Assay: ≥98% (HPLC)
• form: powder
• color: yellow to orange
• solubility: DMSO: >10 mg/mL
• storage temp.: 2-8°C
• SMILES string: Oc1ccc2[nH]c3cc(-c4ccccc4)c5C(=O)NC(=O)c5c3c2c1
• InChI: 1S/C20H12N2O3/c23-11-6-7-14-13(8-11)16-15(21-14)9-12(10-4-2-1-3-5-10)17-18(16)20(25)22-19(17)24/h1-9,21,23H,(H,22,24,25)
• InChI key: IAUZTOZLTFSMIE-UHFFFAOYSA-N

Description

Application

PD-407824 has been used as a wee-1 inhibitor to study its effects on Xenopus laevis embryos. It has also been used as a checkpoint-1 (Chk-1) inhibitor to study its effects on the sensitivity of head and neck squamous carcinoma cells to gemcitabine.

Biochem/physiol Actions

PD-407824 is a Wee1/Chk1 inhibitor.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H315,H319,H335
• Precautionary Statements: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable