P3134
Phosphodiesterase I from Crotalus adamanteus venom
Type VI, crude dried venom
Synonym(s):
5′-Exonuclease, Oligonucleate 5′-nucleotidohydrolase
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About This Item
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Application
Phosphodiesterase (PDE) is any enzyme that is used to breaks phosphodiester bonds. It is a membrane-bound glycoprotein that is used to catalyze the hydrolysis of various nucleotide polyphosphates. Phosphodiesterase I is used in phosphodiesterase activation assays to hydrolyze AMP. Product P3134 is from crude, dried Crotalus adamanteus venom.
Phosphodiesterase I from Crotalus adamanteus venom has been used:
- for cleaving the 3′-5′ internucleotide bonds in the linear chains of the RNA oligomers
- as a model for the hydrolysis of prodrugs in phosphodiesterase assay
- as a component in the nucleotide cleavage buffer
Biochem/physiol Actions
Phosphodiesterase I breaks phosphodiester bonds and catalyzes the hydrolysis of various nucleotide polyphosphates. Phosphodiesterase I is released from eucaryotic plasma membranes by phosphatidylinositol-specific phospholipase C.
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Resp. Sens. 1
Storage Class Code
11 - Combustible Solids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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