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M3184

Sigma-Aldrich

MG 624

≥98%

Synonym(s):

N,N,N-Triethyl-2-(4-trans-stilbenoxy)ethylammonium iodide

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About This Item

Empirical Formula (Hill Notation):
C22H30INO
CAS Number:
77257-42-2
Molecular Weight:
451.38
MDL number:
MFCD00865233
UNSPSC Code:
12352200
PubChem Substance ID:
24278547
NACRES:
NA.77

Assay

≥98%

solubility

DMSO: ≤22 mg/mL
H2O: insoluble

storage temp.

2-8°C

SMILES string

[I-].CC[N+](CC)(CC)CCOc1ccc(cc1)\C=C\c2ccccc2

InChI

1S/C22H30NO.HI/c1-4-23(5-2,6-3)18-19-24-22-16-14-21(15-17-22)13-12-20-10-8-7-9-11-20;/h7-17H,4-6,18-19H2,1-3H3;1H/q+1;/p-1/b13-12+;

InChI key

RDTKUZXIHMTSJO-UEIGIMKUSA-M

Gene Information

human ... CHRNA7(1139)

Biochem/physiol Actions

Nicotinic acetylcholine receptor antagonist; selectively inhibits neuronal nicotinic α-bungarotoxin sensitive receptors that contain the α7 subunit.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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C Gotti et al.
British journal of pharmacology, 124(6), 1197-1206 (1998-08-28)
1. Starting from the structure of an old 4-oxystilbene derivate with ganglioplegic activity (MG624), we synthesized two further derivates (F2 and F3) and two stereoisomers of F3 (F3A and F3B), and studied their selective effect on neuronal nicotinic acetylcholine receptor
Glenn W Vicary et al.
Respiratory research, 18(1), 115-115 (2017-06-04)
Tobacco-related chronic lung diseases are characterized by alterations in lung architecture leading to decreased lung function. Knowledge of the exact mechanisms involved in tobacco-induced tissue remodeling and inflammation remains incomplete. We hypothesize that nicotine stimulates the expression of extracellular matrix

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