H8909

HBcAg core human

~1 mg/mL, ≥95% (SDS-PAGE), recombinant, expressed in E. coli

• Synonym(s): Hepatitis B virus core antigen
• MDL number: MFCD02264925
• UNSPSC Code: 12352202
• NACRES: NA.32

Properties

• recombinant: expressed in E. coli
• Quality Level: 200
• Assay: ≥95% (SDS-PAGE)
• mol wt: 18 kDa
• concentration: ~1 mg/mL
• UniProt accession no.: G9G988
• storage temp.: −20°C
• Gene Information: hepatitis B virus ... HBVgp4(944568) ; human ... HBVgp4(944568)

Description

General description

amino acids 1-183 of HBV core antigen.

Biochem/physiol Actions

HBcAg core human is a capsid protein of hepatitis B virus (HBV). It acts as a viral factor for HBV clearance. HBcAg is implicated in viral replication.

Hepatitis B virus core antigen (HBcAg) is a positive control for human HBV antibodies.In humans with chronic HBV (hepatitis B virus) infection, cytotoxic effects of blood T lymphocytes can be suppressed by incubating cells with antibodies against hepatitis B core antigen (HBcAg). The antigen can also work as a T-cell independent antigen in athymic mice. However, it is an efficient immunogen, resulting in T-cell activation and increased anti-HBc levels. High cytoplasmic/membranous expression of HBcAg is associated with increased liver inflammation.

Physical form

Solution in 50% glycerol, 7.5 mM phosphate buffer, pH 7.2, 75 mM NaCl.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable