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A2754

Sigma-Aldrich

Adenosine 5′-diphosphate sodium salt

bacterial, ≥95% (HPLC)

Synonym(s):

ADP sodium salt, ADP

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About This Item

Empirical Formula (Hill Notation):
C10H15N5O10P2
CAS Number:
20398-34-9
Molecular Weight:
427.20
UNSPSC Code:
41106305
eCl@ss:
32160414
PubChem Substance ID:
24890690
NACRES:
NA.51

biological source

bacterial

Quality Level

300

Assay

≥95% (HPLC)

form

powder

storage temp.

−20°C

SMILES string

[Na].Nc1ncnc2n(cnc12)C3OC(COP(O)(=O)OP(O)(O)=O)C(O)C3O

InChI

1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1

InChI key

XTWYTFMLZFPYCI-KQYNXXCUSA-N

Gene Information

human ... HSP90AA1(3320) , P2RY1(5028)

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General description

Adenosine 5′-diphosphate (ADP) is an adenine nucleotide involved in energy storage and nucleic acid metabolism via its conversion into ATP by FOF1-ATP synthases. ADP can also be obtained by adenylate monophosphate (AMP) reaction catalyzed by adenylate kinase. ADP is a platelet agonist that is secreted from platelet dense granules. It promotes platelet activation through its interaction with ADP receptors P2Y1 and P2Y12. Upon conversion of ADP to adenosine by ecto-ADPases, platelet activation is inhibited via adenosine receptors.

Application

Adenosine 5′-diphosphate sodium salt has been used:
  • as a positive control of platelet aggregation to analyze antiplatelet activity of purified disintegrin by aggregometery.
  • in the preparation of stock solution for a mito stress test.
  • as a positive control in flow cytometry analysis to study the effect of pentameric C-reactive protein (pCRP) and monomeric CRP (mCRP) on the CD62p (P-selectin) expression of platelets.
  • as a platelet agonist to stimulate platelet aggregation.

Storage Class Code

11 - Combustible Solids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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RNA (New York, N.Y.), 15(1), 67-75 (2008-11-27)
The exon junction complex (EJC) is deposited onto spliced mRNAs and is involved in many aspects of mRNA function. We have recently reconstituted and solved the crystal structure of the EJC core made of MAGOH, Y14, the most conserved portion
Richard C Jin et al.
Circulation, 123(18), 1963-1973 (2011-04-27)
Glutathione peroxidase-3 (GPx-3) is a selenocysteine-containing plasma protein that scavenges reactive oxygen species in the extracellular compartment. A deficiency of this enzyme has been associated with platelet-dependent thrombosis, and a promoter haplotype with reduced function has been associated with stroke
Tsui-Fen Chou et al.
Journal of molecular biology, 426(15), 2886-2899 (2014-06-01)
The p97 AAA (ATPase associated with diverse cellular activities), also called VCP (valosin-containing protein), is an important therapeutic target for cancer and neurodegenerative diseases. p97 forms a hexamer composed of two AAA domains (D1 and D2) that form two stacked
Ryosuke Nakata et al.
Scientific reports, 7(1), 17170-17170 (2017-12-08)
Given the rising incidence of non-alcoholic fatty liver disease (NAFLD) in both adults and children, the development of a non-invasive diagnostic method for assessing disease progression to non-alcoholic steatohepatitis (NASH) has become an important research goal. Currently available non-invasive imaging
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