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Y0001151

Hydrastine hydrochloride

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

(1R,9S)-β-Hydrastine hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C21H21NO6 · HCl
CAS Number:
5936-28-7
Molecular Weight:
419.86
MDL number:
MFCD00058100
UNSPSC Code:
41116107
PubChem Substance ID:
329831282
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

hydrastine

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

−20°C

SMILES string

Cl.COc1ccc2[C@H](OC(=O)c2c1OC)[C@@H]3N(C)CCc4cc5OCOc5cc34

InChI

1S/C21H21NO6.ClH/c1-22-7-6-11-8-15-16(27-10-26-15)9-13(11)18(22)19-12-4-5-14(24-2)20(25-3)17(12)21(23)28-19;/h4-5,8-9,18-19H,6-7,10H2,1-3H3;1H/t18-,19+;/m1./s1

InChI key

URBFHJWLYXILMP-VOMIJIAVSA-N

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Hydrastine hydrochloride EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Biochem/physiol Actions

Tyrosine hydroxylase inhibitor. Reduces dopamine content in PC12 cells.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

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Paula N Brown et al.
Journal of AOAC International, 91(4), 694-701 (2008-08-30)
A multilaboratory collaborative study was conducted on a high-performance liquid chromatographic (HPLC) method utilizing UV detection, previously validated using AOAC single-laboratory validation guidelines for determination of hydrastine and berberine in goldenseal (Hydrastis canadensis L.) raw materials, extracts, and dietary supplements
Keivan A Ettefagh et al.
Planta medica, 77(8), 835-840 (2010-12-16)
Goldenseal (Hydrastis canadensis L.) is used to combat inflammation and infection. Its antibacterial activity in vitRO has been attributed to its alkaloids, the most abundant of which is berberine. The goal of these studies was to compare the composition, antibacterial
Alex D Bain et al.
Magnetic resonance in chemistry : MRC, 48(8), 630-641 (2010-07-01)
The INADEQUATE experiment can provide unequalled, detailed information about the carbon skeleton of an organic molecule. However, it also has the reputation of requiring unreasonable amounts of sample. Modern spectrometers and probes have mitigated this problem, and it is now
Shou Yu Yin et al.
Biological & pharmaceutical bulletin, 30(8), 1547-1550 (2007-08-02)
(1R,9S)-beta-hydrastine (BHS) decreases the basal intracellular Ca(2+) concentration ([Ca(2+)](i)) in PC12 cells.(5) This study examined the effects of (1R,9S)-BHS on [Ca(2+)](i) in PC12 cells. (1R,9S)-BHS at 10-100 microM in combination with a high extracellular K+ level (56 mM) inhibited the
M Goel et al.
Folia microbiologica, 48(3), 363-368 (2003-07-26)
(+/-)-alpha-Hydrastine and (+/-)-beta-hydrastine were isolated from Corydalis longipes; both exhibited considerable efficacy against spore germination of some saprophytic and phytopathogenic fungi. While (+/-)-alpha-hydrastine was effective against most of the fungi, Helminthosporium echinoclova was least affected even at the highest dose
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