A4673

Albendazole

analytical standard, ≥98%

• Synonym(s): Methyl 5-(propylthio)-2-benzimidazolecarbamate
• Empirical Formula (Hill Notation): C₁₂H₁₅N₃O₂S
• CAS Number: 54965-21-8
• Molecular Weight: 265.33
• EC Number: 259-414-7
• MDL number: MFCD00083232
• UNSPSC Code: 41116107
• PubChem Substance ID: 329770859
• NACRES: NA.24

Properties

• grade: analytical standard
• Quality Level: 100
• Assay: ≥98%
• technique(s): HPLC: suitable; gas chromatography (GC): suitable
• application(s): forensics and toxicology; pharmaceutical (small molecule)
• format: neat
• SMILES string: CCCSc1ccc2[nH]c(NC(=O)OC)nc2c1
• InChI: 1S/C12H15N3O2S/c1-3-6-18-8-4-5-9-10(7-8)14-11(13-9)15-12(16)17-2/h4-5,7H,3,6H2,1-2H3,(H2,13,14,15,16)
• InChI key: HXHWSAZORRCQMX-UHFFFAOYSA-N

Description

General description

Albendazole is a benzimidazole derivative used for the treatment of human gastrointestinal helmintiasis. It inhibits microtubule and blocks the glucose uptake that causes depletion of glycogen stores and lowering formation of adinosine triphosphate (ATP) in the larval and adult stages of susceptible parasite.

Chemical structure: benzimidazole

Application

Albendazole may be used as a reference standard for the determination of albendazole and its major metabolites, albendazole sulphoxide and albendazole sulphone by high-performance liquid chromatography (HPLC) method in mice plasma.

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Binds to tubulin and inhibits microtubule assembly.

Safety Information

• Pictograms: GHS08,GHS09
• Signal Word: Warning
• Hazard Statements: H361d,H373,H410
• Precautionary Statements: P202 - P260 - P273 - P280 - P308 + P313 - P391
• Hazard Classifications: Aquatic Acute 1 - Aquatic Chronic 1 - Repr. 2 - STOT RE 2 Oral
• Target Organs: Adrenal gland,Blood,male reproductive organs,spleen
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves