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30494

Supelco

Silydianin

analytical standard

Synonym(s):

Silidianin

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About This Item

Empirical Formula (Hill Notation):
C25H22O10
CAS Number:
29782-68-1
Molecular Weight:
482.44
EC Number:
249-848-5
MDL number:
MFCD09970974
UNSPSC Code:
85151701
PubChem Substance ID:
329753521
NACRES:
NA.24

grade

analytical standard

Quality Level

100

Assay

≥95.0% (HPLC)

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

impurities

≤10.0% residual solvents (GC-HS)
≤10.0% water

application(s)

food and beverages

format

neat

storage temp.

2-8°C

SMILES string

COc1cc(ccc1O)[C@@H]2[C@H]3CO[C@]4(O)[C@H]3C(=C[C@H]2C4=O)[C@H]5Oc6cc(O)cc(O)c6C(=O)[C@@H]5O

InChI

1S/C25H22O10/c1-33-16-4-9(2-3-14(16)27)18-11-7-12(20-13(18)8-34-25(20,32)24(11)31)23-22(30)21(29)19-15(28)5-10(26)6-17(19)35-23/h2-7,11,13,18,20,22-23,26-28,30,32H,8H2,1H3/t11-,13-,18+,20+,22+,23-,25-/m1/s1

InChI key

CYGIJEJDYJOUAN-JSGXPVSSSA-N

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Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
BCCH9043
BCCH2888
BCCH0751
BCCG9020
BCCG2616

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Silybin and silydianin diminish the oxidative metabolism of human polymorphonuclear neutrophils.
E Ignatowicz et al.
Acta biochimica Polonica, 44(1), 127-129 (1997-01-01)
János Fehér et al.
Orvosi hetilap, 149(51), 2413-2418 (2008-12-17)
In the treatment of chronic liver diseases adequate therapy can be chosen only in the knowledge of pathogenetic processes. In the liver diseases caused by oxidative stress (alcoholic and non-alcoholic fatty liver and steatohepatitis, drug and compound induced liver toxicity)
Małgorzata Zielińska-Przyjemska et al.
Phytotherapy research : PTR, 20(2), 115-119 (2006-01-31)
The inhibitory effect of silydianin, an active constituent of Silybium marianum, on the in vitro production and release of oxidative products has been examined. Polymorphonuclear neutrophils (PMNs) play a primary role in the initiation and propagation of inflammatory responses. Their
James I Lee et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 845(1), 95-103 (2006-09-01)
A sensitive method for the simultaneous quantitation of six active constituents in commercial silymarin standardized extracts was developed based on liquid chromatography (LC) in combination with mass spectrometry (MS). The six main active constituents, namely, silydianin, silychristin, diastereoisomers of silybin
Z Varga et al.
Phytotherapy research : PTR, 15(7), 608-612 (2001-12-18)
The mixture of flavonolignans [Legalon: silybin (2a), isosilybin (3), silydianin (4) and silychristin (5)] and derivatives of silybin (2b-d) were assessed for their inhibitory activity on the oxidative burst of PMA-stimulated human PMNLs. The inhibitory effect of flavonolignans on O(2)(-)
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