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Key Documents

MAB5504

Sigma-Aldrich

Anti-Vesicular Glutamate Transporter 2 Antibody

clone 8G9.2, Chemicon®, from mouse

Synonym(s):

VGLUT2

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

Quality Level

100

antibody form

purified antibody

antibody product type

primary antibodies

clone

8G9.2, monoclonal

species reactivity

mouse, rat

species reactivity (predicted by homology)

human

manufacturer/tradename

Chemicon®

technique(s)

immunohistochemistry: suitable
western blot: suitable

isotype

IgG1

NCBI accession no.

NM_020346.1

UniProt accession no.

Q9JI12

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... SLC17A6(57084)

General description

Vesicular Glutamate Transporter 2 (VGLUT2) is a sodium dependent inorganic phosphate cotransporter that is involved in the calcium dependent glutamate release from astrocytes. It is expressed in only a subset of neurons, localized to synaptic vesicles, at synapses exhibiting classical excitatory features. VGLUT2 mRNA is found in brain regions that lack VGLUT1, a related protein also displaying sodium dependent inorganic phosphate cotransporter activity.

Specificity

Reacts with VGLUT2 (Vesicular Glutamate Transporter 2).

Application

Detect Vesicular Glutamate Transporter 2 using this Anti-Vesicular Glutamate Transporter 2 Antibody validated for use in WB, IH.
Immunohistochemistry: A 1:50-1:300 dilution of a previous lot worked using ABC with NiDAB on floating mouse brain sections.

Optimal working dilutions must be determined by end user.

Quality

Evaluated by Western Blot on Mouse brain lysates.

Western Blotting Analysis: 1:500 dilution of this antibody detected VGLUT2 on 10 µg of Mouse brain lysates.

Target description

56 kDa

Physical form

Format: Purified
Mouse monoclonal in PBS containing 0.1% sodium azide.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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B Fyk-Kolodziej et al.
Neuroscience, 178, 218-239 (2011-01-08)
An immunocytochemical comparison of vGluT1 and vGluT3 in the cochlear nucleus (CN) of deafened versus normal hearing rats showed the first example of vGluT3 immunostaining in the dorsal and ventral CN and revealed temporal and spatial changes in vGluT1 localization
A bushy cell network in the rat ventral cochlear nucleus.
Ricardo Gomez-Nieto,Maria E Rubio
The Journal of Comparative Neurology null
SCA1-like disease in mice expressing wild-type ataxin-1 with a serine to aspartic acid replacement at residue 776.
Duvick, L; Barnes, J; Ebner, B; Agrawal, S; Andresen, M; Lim, J; Giesler, GJ; Zoghbi, HY; Orr, HT
Neuron null
Y Cai et al.
Neuroscience, 215, 160-173 (2012-05-01)
The glomeruli are the first synaptic relay on the olfactory pathway and play a basic role in smell perception. Glomerular degeneration occurs in humans with age and in Alzheimer's disease (AD). The glomeruli heavily express β-amyloid precursor protein (APP), β-secretase
I Pose et al.
Neuroscience, 172, 246-255 (2010-11-04)
The rostral ventro-medial medullary reticular formation is a complex structure that is involved with a variety of motor functions. It contains glycinergic neurons that are activated during active (rapid eye movement (REM)) sleep (AS); these neurons appear to be responsible
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