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Key Documents

ABD85

Sigma-Aldrich

Anti-PAX3/7BP Antibody

serum, from rabbit

Synonym(s):

PAX3 binding protein 1, PAX7 binding protein 1, GC-rich sequence DNA-binding factor 1

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

serum

antibody product type

primary antibodies

clone

polyclonal

species reactivity

rat, mouse, human

technique(s)

immunoprecipitation (IP): suitable
western blot: suitable

UniProt accession no.

Q9Y5B6

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

mouse ... Paxbp1(67367)

General description

In skeletal muscles, Pax7 uniquely marks muscle satellite cells and plays some important yet unknown functions at the perinatal stage. Pax3/7BP is a ubiquitously expressed nuclear protein, enriched in Pax7+ muscle precursor cells (MPCs), and serves as an indispensable adaptor for Pax7 to recruit the histone-3-lysine-4 (H3K4) methyltransferase (HMT) complex by bridging Pax7 and Wdr5. Recently, Wu et al. have established Pax3/7BP as an essential adaptor linking Pax3/7 with the H3K4 HMT to regulate the proliferation of muscle progenitor cells.

Immunogen

Recombinant protein corresponding to mouse PAX3/7BP.

Application

Anti-PAX3/7BP Antibody is an antibody against PAX3/7BP for use in western blotting & IP.
Research Category
Stem Cell Research
Research Sub Category
Muscle Physiology

Developmental Signaling

Quality

Evaluated by Western Blot in a jurkat cell lysate.
Western Blot Analysis: A 1:1000 dilution of this antibody detected Pax3/7BP in a 10 µg jurkat cell lysate.

Target description

~105 kDa observed. Uncharacterized bands may be observed in some lysate(s).

Physical form

Unpurified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Certificates of Analysis (COA)

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Yarui Diao et al.
Cell stem cell, 11(2), 231-241 (2012-08-07)
In mouse skeletal muscles, Pax7 uniquely marks muscle satellite cells and plays some important yet unknown functions at the perinatal stage. To elucidate its in vivo functions, we initiated a yeast two-hybrid screening to look for Pax7-interacting proteins and identified

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