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Key Documents

8.18215

Sigma-Aldrich

Tetra-n-butylammonium hydroxide

(12.5% solution in methanol) for synthesis

Synonym(s):

Tetrabutylammonium hydroxide

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About This Item

UNSPSC Code:
12352107
NACRES:
NA.22

Quality Level

200

expl. lim.

5.5-36.5 % (v/v) Methanol)

bp

65 °C/1013 hPa

transition temp

flash point 11 °C

density

0.81 g/cm3 at 20 °C

storage temp.

2-30°C

Application

  • Biological Acid Anion Research: Tetra-n-butylammonium hydroxide is used in the hydration structures of lactic acid, facilitating the formation of ionic clathrate hydrate with biological organic acid anions. This application is significant in the study of biological molecules and their interactions with water molecules in various conditions (Muromachi et al., 2014).
  • Pharmaceutical Analysis: It is used in the determination of calcium dobesilate in human plasma, utilizing ion-pairing extraction and high-performance liquid chromatography. This method is crucial for monitoring drug levels in patients, ensuring therapeutic efficacy and safety (Róna et al., 2001).

Analysis Note

Assay (acidimetric): 11.5 - 13.5 %
Density (d 20 °C/ 4 °C): 0.815 - 0.830

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Eye Dam. 1 - Flam. Liq. 2 - Skin Corr. 1B - Skin Sens. 1 - STOT SE 1

Storage Class Code

3 - Flammable liquids

WGK

WGK 3

Flash Point(F)

51.8 °F

Flash Point(C)

11 °C

Certificates of Analysis (COA)

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