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574661

Sigma-Aldrich

Survivin Antagonist, S12

The Survivin Antagonist, S12 controls the biological activity of Survivin.

Synonym(s):

Survivin Antagonist, S12, Survivin Inhibitor II, 3-(2-(benzo[d][1,3]dioxol-5-yl)-2-oxoethyl)-5-bromo-3-hydroxyindolin-2-one

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10 μG
641,00 CHF

641,00 CHF

Estimated to ship on16 de mayo de 2025

To order products, please contact your local dealer.
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10 μG
641,00 CHF

About This Item

Empirical Formula (Hill Notation):
C17H12BrNO5
CAS Number:
258264-62-9
Molecular Weight:
390.18
MDL number:
MFCD00117860
UNSPSC Code:
12352200
NACRES:
NA.77

641,00 CHF

Estimated to ship on16 de mayo de 2025

To order products, please contact your local dealer.

Quality Level

100

Assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

white

solubility

DMSO: 50 mg/mL, nearly colorless

shipped in

ambient

storage temp.

−20°C

SMILES string

O=C(CC1(C(C=C(Br)C=C2)=C2NC1=O)O)C3=CC(OCO4)=C4C=C3

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technique(s)

activity assay: suitable (kinase)

technique(s)

activity assay: suitable (phosphatase)

technique(s)

activity assay: suitable (kinase)

technique(s)

activity assay: suitable (kinase)

biological source

human

biological source

human

biological source

human

biological source

human

form

liquid

form

solution

form

-

form

-

mol wt

Mw 40.7 kDa

mol wt

Mw 37.6 kDa

mol wt

Mw 68.9 kDa

mol wt

Mw 79.5 kDa

storage temp.

−70°C

storage temp.

−20°C

storage temp.

-

storage temp.

-

General description

A cell-permeable hydroxyindolinone compound that acts as a selective antagonist of survivin. Induces mitotic arrest and blocks cell cycle at G2/M phase (~40 µM in HeLA cells) leading to apoptotic cell death. Shown to bind to a specific cavity adjacent to the interface involved in the dimerization of survivin. Binding is specific only to native survivin and does not affect any mutant forms. Inhibits HCT116 cell proliferation independently of their p53 status and reduces tumor volume in xenograft models in a dose-dependent manner (5 to 15 mg/kg).

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Berezov, A., et al. 2011. Oncogene31, 1938.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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