475984

MyoVin-1

A pyrazolopyrimidine compound that blocks ADP release from the actomyosin complex and acts as a potent, reversible and uncompetitive inhibitor of actin-stimulated ATPase activity of myosin V.

• Synonym(s): MyoVin-1, Myosin V Inhibitor 1
• Empirical Formula (Hill Notation): C₂₉H₂₆N₆O₃S
• CAS Number: 1259177-59-7
• Molecular Weight: 538.62
• MDL number: MFCD32009180
• UNSPSC Code: 12352200
• NACRES: NA.51

Properties

• Quality Level: 100
• Assay: ≥95% (HPLC)
• form: powder
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: pale yellow
• solubility: DMSO: 50 mg/mL
• shipped in: ambient
• storage temp.: −20°C
• SMILES string: O=C(C1=CC=CC(SCC2=CC=CC(NC3=NC(NN=C4C5=CC=C(N6CCOCC6)C=C5)=C4C=N3)=C2)=C1)O

Description

General description

A pyrazolopyrimidine compound that blocks ADP release from the actomyosin complex and acts as a potent, reversible and uncompetitive inhibitor of actin-stimulated ATPase activity of myosin V (K_i = 6.3 and 5.5 µM by single- and double-headed myosin V). Displays excellent selectivity over myosin II and myosin IV (<10% inhibition at 50 µM) and only minimally inhibits the kinase activity of Cdk1/B, CHK1, Plk1, Abl, ERK2, CKII and Aurora-B (<10% inhibition at 100 µM).

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Islam, K., et al. 2010. Angew. Chem. Int. Ed.49, 8484.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable