700039P

24(S),25-epoxycholesterol

Avanti Polar Lipids

• Synonym(s): (24S,25)-Epoxycholesterol, (3β,24S)-24,25-Epoxycholest-5-en-3-ol
• Empirical Formula (Hill Notation): C₂₇H₄₄O₂
• CAS Number: 77058-74-3
• Molecular Weight: 400.64
• UNSPSC Code: 12352211
• NACRES: NA.25

Properties

• form: powder
• packaging: pkg of 1 × 1 mg (700039P-1mg); pkg of 1 × 5 mg (700039P-5mg)
• manufacturer/tradename: Avanti Polar Lipids
• shipped in: dry ice
• storage temp.: −20°C
• InChI: 1S/C27H44O2/c1-17(6-11-24-25(2,3)29-24)21-9-10-22-20-8-7-18-16-19(28)12-14-26(18,4)23(20)13-15-27(21,22)5/h7,17,19-24,28H,6,8-16H2,1-5H3/t17-,19+,20+,21-,22+,23+,24+,26+,27-/m1/s1
• InChI key: OSENKJZWYQXHBN-XVYZBDJZSA-N

Description

General description

24(S),25-epoxycholesterol is an oxysterol, which is produced by fibroblasts, macrophages and brain cells.

24(S),25-epoxycholesterol is a cholesterol-derived oxysterol, which is produced by fibroblasts, macrophages, and the brain cells. 24(S),25-epoxycholesterol is synthesized de novo in the mevalonate pathway.

Application

24(S),25-epoxycholesterol has been used as an oxysterol/internalstandard to study the effects of AY9944-induced changes in neurospheres.

Biochem/physiol Actions

Exogenous addition of 24(S),25-epoxycholesterol lowers 3-hydroxy-3-methylglutaryl-Coenzyme A (HMG-CoA) reductase activity, represses sterol regulatory element-binding protein (SREBP) processing, and induces liver × receptor (LXR) -gene targets in vitro.

Packaging

5 mL Amber Glass Screw Cap Vial (700039P-1mg)

5 mL Amber Glass Screw Cap Vial (700039P-5mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Safety Information

• Storage Class Code: 11 - Combustible Solids