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CF0041

Sigma-Aldrich

Urea crosslinker – C4-arm, NHS ester (DSBU, BuUrBU)

Synonym(s):

1,1′-Bis(2,5-dioxo-1-pyrrolidinyl) 4,4′-(carbonyldiimino)bis[butanoate], Disuccinimidyldibutyric urea

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About This Item

Linear Formula:
C17H22N4O9
CAS Number:
1240387-33-0
MDL number:
MFCD30738322
UNSPSC Code:
12161502
NACRES:
NA.22

form

solid

reaction suitability

reaction type: C-C Bond Formation
reagent type: cross-linking reagent

SMILES string

N2(C(=O)CCC2=O)OC(=O)CCCNC(=O)NCCCC(=O)ON1C(=O)CCC1=O

InChI

1S/C17H22N4O9/c22-11-5-6-12(23)20(11)29-15(26)3-1-9-18-17(28)19-10-2-4-16(27)30-21-13(24)7-8-14(21)25/h1-10H2,(H2,18,19,28)

Application

The ureido-4,4´-dibutyric acid bis(hydroxysuccinimide) ester, also known as DSBU or BuUrBU, is the longest version of MS-cleavable urea-based lysine-lysine reactive homobifunctional cross-linkers, featuring a C4-arm. At neutral or slightly basic pH, it irreversibly crosslinks the neighbouring lysine groups. The presence of the symmetrical urea moiety which is prone to collision-induced dissociation allows for the unambiguous distinguishing of crosslinks in tandem CID-MS experiments.

Legal Information

Product of CF Plus Chemicals.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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