920541
tert-Butyl 1-oxa-4,9-diazaspiro[5.6]dodecane-9-carboxylate
Synonym(s):
Rigid linker for PROTAC® development
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About This Item
Empirical Formula (Hill Notation):
C14H26N2O3
CAS Number:
Molecular Weight:
270.37
MDL number:
UNSPSC Code:
12352106
NACRES:
NA.22
Recommended Products
form
solid
Quality Level
reaction suitability
reagent type: linker
functional group
Boc
storage temp.
2-8°C
SMILES string
CC(C)(OC(N1CCCC2(CC1)CNCCO2)=O)C
Application
tert-Butyl 1-oxa-4,9-diazaspiro[5.6]dodecane-9-carboxylate is useful as a rigid linker in PROTAC development for targeted protein degradation as well as chemical conjugates. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties. Developed in partnership with ComInnex.
Similar to CH4979588668
Similar to CH4979588668
Other Notes
Legal Information
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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