914665
Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol) diacrylate
average Mn ~14,600
Synonym(s):
F-108 diacrylate, PEG-PPG-PEG, Pluronic diacrylate
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Application
Poloxamers are nonionic, triblock copolymers containg a central hydrophobic chain of poly(propylene glycol) (PPG) and two terminal hydrophilic chains of poly(ethylene glycol) (PEG). Due to their amphiphilic structure, poloxamer solutions feature temperature dependent self-assembling and thermo-gelling behavior. Concentrated aqueous solutions of poloxamers are liquid at low temperature and form a gel at higher temperature, in a reversible process. This characteristic has allowed for these materials to be used as drug carriers for most routes of administration including oral, topical, intranasal, ocular, and parenteral. Acrylate-modified derivatives are most commonly used as thermosensitive hydrogels for drug delivery and 3D bioprinting applications. After casting or printing, the material can be crosslinked to preserve the hydrogel structure.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Self-Assembly of Pluronic F127 Diacrylate in Ethylammonium Nitrate: Structure, Rheology, and Ionic Conductivity before and after Photo-Cross-Linking.
Carlos R L, et al.
Macromolecules, 49(14), 5179-5189 (2016)
Smart hydrogels for 3D bioprinting.
Shuai W, et al.
International Journal of Bioprinting, 1(1), 3-14 (2015)
Application of thermoreversible pluoronic F-127 gels in Pharmaceutical formulations.
Escobar-Chavez J J, et al.
J. Pharm. Pharm. Sci., 9(3), 339-358 (2006)
Self-Assembly of Pluronic F127 Diacrylate in Ethylammonium Nitrate: Structure, Rheology, and Ionic Conductivity before and after Photo-Cross-Linking.
Lopez Barron C R, et al.
Macromolecules, 49(14), 5179-5189 (2016)
Smart hydrogels for 3D bioprinting.
Wang S, et al.
International Journal of Bioprinting, 1(1), 3-14 (2015)
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