902241

N-Hydroxysuccinimide poly(ethylene glycol)-block-poly(lactide-co-glycolide)

PEG average M_n 5000, PLGA average M_n 15000, lactide:glycolide 50:50

• Synonym(s): NHS-PEG-b-PLGA, NHS-PEG-PLGA
• Linear Formula: C₁₀H₁₄O₅NS(C₂H₄O)_nC₂H₄O[(C₂H₂O₂)_x(C₃H₄O₂)_y]_mH
• UNSPSC Code: 12352111
• NACRES: NA.23

Properties

• form: powder
• feed ratio: lactide:glycolide 50:50; lactide:glycolide 50:50±5
• mol wt: PEG M_n 4000-6000 g/mol (by NMR); PEG average M_n 5000; PLGA M_n 13500-16500 g/mol (by NMR); PLGA average M_n 15000
• color: white
• suitability: conforms to structure for NMR
• storage temp.: −20°C

Description

Application

N-Hydroxysuccinimide poly(ethylene glycol)-block-poly(lactide-co-glycolide) is a N-hydroxysuccinimide (NHS)-functionalized, biocompatible, amphiphilic block copolymer. Due to its self-assembling properties, this material can be used in the formation of nanoparticles for drug delivery. Additionally, due to the NHS-functionalization of the PEG block, this material can be used to rapidly covalently conjugate biomolecules, API, or targeting ligands. Potential uses include the targeted and/or controlled release of cancer drugs, anti-inflammatory drugs, antibiotics, or anesthetic agents.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable