809608
Biotin-2′,2′,3′,3′-d4
≥98 atom % D, ≥95% (CP)
Synonym(s):
Vitamin B7-d4, Vitamin B8-d4, Vitamin H-d4
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About This Item
Empirical Formula (Hill Notation):
C10D4H12N2O3S
Molecular Weight:
248.34
UNSPSC Code:
12352106
PubChem Substance ID:
NACRES:
NA.12
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isotopic purity
≥98 atom % D
Quality Level
Assay
≥95% (CP)
form
powder
technique(s)
mass spectrometry (MS): suitable
color
white to off-white
mp
228 °C
mass shift
M+4
storage temp.
−20°C
SMILES string
OC(CC([2H])([2H])C([2H])([2H])C[C@@H]1SC[C@@]2([H])[C@]1([H])NC(N2)=O)=O
InChI
1S/C10H16N2O3S/c13-8(14)4-2-1-3-7-9-6(5-16-7)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15)/t6-,7-,9-/m0/s1/i1D2,2D2
InChI key
YBJHBAHKTGYVGT-CCSQOTJNSA-N
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General description
Biotin is a water-soluble vitamin B which is also known as vitamin B7. It is involved in the synthesis of fatty acids and gluconeogenesis. Biotin is found in plants and animals. Its deficiency causes retardation in growth, alopecia and neurological impairment in humans and animals.
Biotin-2′,2′,3′,3′-d4 is an isotope of vitamin B7 wherein C-2′, C-2′, C-3′, C-3′ protons are replaced by deuterium.
Biotin-2′,2′,3′,3′-d4 is an isotope of vitamin B7 wherein C-2′, C-2′, C-3′, C-3′ protons are replaced by deuterium.
Application
Biotin-2′,2′,3′,3′-d4 can be used as a stable isotope internal standard for accurate data interpretation in specific biological samples.
Storage Class Code
11 - Combustible Solids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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A IJpelaar et al.
Clinical biochemistry, 83, 78-80 (2020-05-31)
Despite the increasing awareness about biotin interference with immunoassays, so far, only two studies have quantified the prevalence of elevated biotin in patient populations. In a US study, over 7% had biotin concentrations exceeding 10 ng/mL, whereas in an Australian study
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Cyran CC, et al.
Investigative Radiology, 43(5), 298-298 (2008)
Agar plate method using Lactobacillus plantarum for biotin determination in serum and urine
FUKUI T, et al.
J. Nutr. Sci. Vitaminol., 40(5), 491-498 (1994)
Factitious Graves disease due to biotin immunoassay interference-a case and review of the literature
Elston MS, et al.
The Journal of clinical endocrinology and metabolism, 101(9), 3251-3255 (2016)
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