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719935

Sigma-Aldrich

Resomer® R 203 S, Poly(D,L-lactide)

ester terminated, Mw 18,000-28,000

Synonym(s):

Lactide polymer, PDLLA

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About This Item

Linear Formula:
[C3H4O2]x[C2H2O2]y
CAS Number:
202832-99-3
UNSPSC Code:
12162002
NACRES:
NA.23

Quality Level

200

form

amorphous

mol wt

Mw 18,000-28,000

degradation timeframe

<6 months

viscosity

0.25-0.35 dL/g, 0.1 % (w/v) in chloroform(25 °C, Ubbelohde) (size 0c glass capillary viscometer)

transition temp

Tg 46-50 °C

storage temp.

2-8°C

SMILES string

[H]OC(C(OC(C(O[R])=O)C)=O)C

InChI

1S/C6H8O4.C4H4O4/c1-3-5(7)10-4(2)6(8)9-3;5-3-1-7-4(6)2-8-3/h3-4H,1-2H3;1-2H2

InChI key

LCSKNASZPVZHEG-UHFFFAOYSA-N

General description

Ester terminated Poly(D,L-lactide) (PDLLA, RESOMER® ) is a copolymer of L and D-lactic acid and (or L and D lactide). The structure is highly irregular and amorphous. RESOMER® polymers are bioresorbable aliphatic polyesters comprised of a range of different ratios of lactide and glycolide monomers, PLA stereochemistries, and end-group functionalization.

Application

This biodegradable polyester is useful for the controlled release of drugs both in vitro and in vivo.

Legal Information

Product of Evonik
RADIANT is a registered trademark of Bio-Rad Laboratories, Inc.
RESOMER is a registered trademark of Evonik Rohm GmbH

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
BCCD0968
BCCB8258
BCBW5330
BCBT1096
BCBQ3416V

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Biodegradable polyesters for controlled release of trypanocidal drugs: in vitro and in vivo studies.
Lemmouchi Y, et al.
Biomaterials, 19(20), 1827-1837 (1998)
Auras RA, et al.
Poly(lactic acid): Synthesis, Structures, Properties, Processing, and Application null

Articles

RESOMER® - Biodegradable Polymers for Sutures, Medical Devices, Drug Delivery Systems and Tissue Engineering

Interest in utilizing biodegradable polymers for biomedical applications has grown since the 1960s.

Biodegradable Polyester-based Nanoparticle Formation by Miniemulsion Technique

Aliphatic polyesters such as polylactide, poly(lactide-co-glycolide) and polycaprolactone, as well as their copolymers, represent a diverse family of synthetic biodegradable polymers that have been widely explored for medical uses and are commercially available.

Biodegradable Polyester Based Nanoparticle Formation by Miniemulsion Technique

Aliphatic polyesters such as polylactide, poly(lactide-co-glycolide) and polycaprolactone, as well as their copolymers, represent a diverse family of synthetic biodegradable polymers that have been widely explored for medical uses and are commercially available.

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