667005

(R)-(+)-3,3,3-Trifluoro-1,2-epoxypropane

97%

• Synonym(s): (R)-(+)-2-(Trifluoromethyl)oxirane
• Empirical Formula (Hill Notation): C₃H₃F₃O
• CAS Number: 143142-90-9
• Molecular Weight: 112.05
• MDL number: MFCD08276876
• UNSPSC Code: 12352005
• PubChem Substance ID: 24884878
• NACRES: NA.22

Properties

• Quality Level: 100
• Assay: 97%
• refractive index: n20/D <1.300
• bp: 25-32 °C
• density: 1.294 g/mL at 25 °C
• storage temp.: 2-8°C
• SMILES string: FC(F)(F)[C@H]1CO1
• InChI: 1S/C3H3F3O/c4-3(5,6)2-1-7-2/h2H,1H2/t2-/m1/s1
• InChI key: AQZRARFZZMGLHL-UWTATZPHSA-N

Description

Application

(R)-(+)-3,3,3-Trifluoro-1,2-epoxypropane can be used as a substrate to synthesize:

• Substituted trifluoro amino propanols, which are found to be potent inhibitors of cholesteryl ester transfer protein.
• (2R) Trifluoro-(methoxybenzyloxy)-propanol (chiral glycol) by reacting with 4-methoxybenzyl alcohol in the presence of NaH. Chiral glycol intermediate is further utilized for the preparation of trifluoromethyl glycol carbamates as potential monoacylglycerol lipase (MAGL) inhibitors.

Safety Information

• Pictograms: GHS02
• Signal Word: Danger
• Hazard Statements: H224
• Precautionary Statements: P210 - P403 + P233
• Hazard Classifications: Flam. Liq. 1
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 3
• Flash Point(F): -14.8 °F
• Flash Point(C): -26 °C
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves