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643440

Sigma-Aldrich

L-Arginine-13C6 hydrochloride

99 atom % 13C, 95% (CP)

Synonym(s):

SILAC Amino Acid, (S)-(+)-2-Amino-5-[(aminomethyl)amino]pentanoic acid-13C6 hydrochloride, 13C Labeled arginine, 13C Labeled arginine hydrochloride

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About This Item

Linear Formula:
H2N13C(NH)NH13CH2(13CH2)213CH(NH2)13CO2H · HCl
CAS Number:
Molecular Weight:
216.62
MDL number:
UNSPSC Code:
12352209
PubChem Substance ID:
NACRES:
NA.12

Pricing and availability is not currently available.

isotopic purity

99 atom % 13C

Quality Level

Assay

95% (CP)

form

solid

optical activity

[α]20/D +22°, c = 12 in 10% HCl

technique(s)

protein expression: suitable

mp

226-230 °C (dec.) (lit.)

mass shift

M+6

SMILES string

Cl[H].N[13C@@H]([13CH2][13CH2][13CH2]N[13C](N)=N)[13C](O)=O

InChI

1S/C6H14N4O2.ClH/c7-4(5(11)12)2-1-3-10-6(8)9;/h4H,1-3,7H2,(H,11,12)(H4,8,9,10);1H/t4-;/m0./s1/i1+1,2+1,3+1,4+1,5+1,6+1;

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This Item
PZ0273PZ0296PZ0401
form

powder

form

powder

form

powder

form

powder

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

room temp

storage temp.

room temp

storage temp.

room temp

storage temp.

2-8°C

solubility

DMSO: 20 mg/mL, clear

solubility

DMSO: 10 mg/mL, clear

solubility

DMSO: 5 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

color

, white to yellow to brown

color

white to beige

color

white to beige

color

white to beige

Application

Pulsed Stable Isotope labeling of amino acid has been used to study host-cell function, survival, the precise intracellular pathways in protein synthesis of HIV-1 infected human monocytederived macrophages. Identification of viral proteins from coronavirus infectious bronchitis-infected cells has been achieved with Stable Isotope labeling in conjunction with LC-MS/MS.

Packaging

This product may be available from bulk stock and can be packaged on demand. For information on pricing, availability and packaging, please contact Stable Isotopes Customer Service.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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    Gino L Turra et al.
    Microbiology spectrum, 9(2), e0080921-e0080921 (2021-09-30)
    Import and oxidative folding of proteins in the mitochondrial intermembrane space differ among eukaryotic lineages. While opisthokonts such as yeast rely on the receptor and oxidoreductase Mia40 in combination with the Mia40:cytochrome c oxidoreductase Erv, kinetoplastid parasites and other Excavata/Discoba
    Stephanie D Kraft-Terry et al.
    Journal of proteome research, 10(6), 2852-2862 (2011-04-20)
    Dynamic interactions between human immunodeficiency virus-1 (HIV-1) and the macrophage govern the tempo of viral dissemination and replication in its human host. HIV-1 affects macrophage phenotype, and the macrophage, in turn, can modulate the viral life cycle. While these processes
    Zehan Hu et al.
    Cell reports, 28(13), 3486-3496 (2019-09-26)
    The target of rapamycin complex 1 (TORC1) is a master regulator of cell homeostasis, which promotes anabolic reactions and synchronously inhibits catabolic processes such as autophagy-mediated protein degradation. Its prime autophagy target is Atg13, a subunit of the Atg1 kinase
    Koshi Imami et al.
    Molecular cell, 72(1), 84-98 (2018-09-18)
    Emerging evidence indicates that heterogeneity in ribosome composition can give rise to specialized functions. Until now, research mainly focused on differences in core ribosomal proteins and associated factors. The effect of posttranslational modifications has not been studied systematically. Analyzing ribosome
    Ye Dee Tay et al.
    Cell reports, 26(6), 1654-1667 (2019-02-07)
    NDR/LATS kinases regulate multiple aspects of cell polarity and morphogenesis from yeast to mammals. Fission yeast NDR/LATS kinase Orb6 has been proposed to control cell polarity by regulating the Cdc42 guanine nucleotide exchange factor Gef1. Here, we show that Orb6

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