244929
Dichloro(ethylenediamine)platinum(II)
99%
Synonym(s):
Dichloro(1,2-diaminoethane)platinum, Dichloro(1,2-ethanediamine)platinum, Platinum ethylenediamine dichloride
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About This Item
Linear Formula:
(H2NCH2CH2NH2)PtCl2
CAS Number:
Molecular Weight:
326.08
EC Number:
MDL number:
UNSPSC Code:
12161600
PubChem Substance ID:
NACRES:
NA.22
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Assay
99%
form
solid
reaction suitability
core: platinum
reagent type: catalyst
SMILES string
Cl[Pt]Cl.NCCN
InChI
1S/C2H8N2.2ClH.Pt/c3-1-2-4;;;/h1-4H2;2*1H;/q;;;+2/p-2
InChI key
LMABILRJNNFCPG-UHFFFAOYSA-L
Related Categories
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Target Organs
Respiratory system
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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S A Shalimov et al.
Klinicheskaia khirurgiia, (8)(8), 36-38 (1994-01-01)
Results of the action of a preparation consisting of cis-dichlorodiammineplatinum and deoxyribonucleic acid combined in the saline balanced solution by means of the original technique on cytomegalovirus infection of patients with cancer of the liver are presented. Clearly pronounced antivirus
T W Hambley et al.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 6(5-6), 534-542 (2001-07-27)
The rate and extent of binding of [PtCl2(hpip)] (hpip=homopiperazine-1,4-diazacycloheptane) and cis-[PtCl2(NH3)2] to calf thymus DNA was measured using atomic absorption spectroscopy and it was found that [PtCl2(hpip)] bound both more rapidly and to a greater extent than did cis-[PtCl2(NH3)2]. The
A P Jekunen et al.
Cancer research, 54(10), 2680-2687 (1994-05-15)
The cellular pharmacology of the tritium-labeled cisplatin analogue dichloro(ethylenediamine)platinum(II) ([3H]DEP) was compared in cisplatin-sensitive 2008 and resistant 2008/C13*5.25 human ovarian carcinoma cells. The cellular content of total [3H], ultrafiltrable [3H], and free native [3H]DEP was measured during and following incubation
J D Bell et al.
Journal of inorganic biochemistry, 31(4), 241-246 (1987-12-01)
Reactions of cis-PtCl2(NH3)2 (1), Pt(1,2-diaminoethane)Cl2 (2), PtCl4(2-) (3), and AuCl4- (4) with intact cell culture media have been studied by spin-echo 500 MHz proton NMR spectroscopy. This has allowed us to observe reactions of components of the media at submillimolar
A Eastman
Chemico-biological interactions, 61(3), 241-248 (1987-03-01)
Glutathione can modulate the toxicity of a variety of drugs, although its role in modulating toxicity by anticancer platinum drugs is ambivalent. At physiologically relevant concentrations, glutathione can inhibit the reaction between DNA and cis-dichloro(ethylenediamine)platinum(II) (cis-DEP). Glutathione can also react
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