174823

4-Quinolinecarboxylic acid

97%

• Empirical Formula (Hill Notation): C₁₀H₇NO₂
• CAS Number: 486-74-8
• Molecular Weight: 173.17
• Beilstein: 5224
• EC Number: 207-640-1
• MDL number: MFCD00006782
• UNSPSC Code: 12352100
• PubChem Substance ID: 24850356
• NACRES: NA.22

Properties

• Assay: 97%
• mp: 254-255 °C (lit.)
• SMILES string: OC(=O)c1ccnc2ccccc12
• InChI: 1S/C10H7NO2/c12-10(13)8-5-6-11-9-4-2-1-3-7(8)9/h1-6H,(H,12,13)
• InChI key: VQMSRUREDGBWKT-UHFFFAOYSA-N

Description

Application

4-Quinolinecarboxylic acid was used in the coupling reaction with diamine linker. A 4-quinolinecarboxylic acid analogue, brequinar sodium was used to inhibit dihydroorotate dehydrogenase and the de novo biosynthesis of pyrimidine.

Biochem/physiol Actions

4-Quinolinecarboxylic acid showed anti-tumor activity against L1210 leukemia and B16 melanoma.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H315,H319,H335
• Precautionary Statements: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves