C0620

CDK4/Cyclin D1, active, GST tagged human

PRECISIO^® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

• Synonim(y): BCL1, CMM3, D11S2878E, MG Cl4458, PRAD1, PSK-J3, U21 B31
• Kod UNSPSC: 12352200
• NACRES: NA.32

Właściwości

• rekombinowane: expressed in baculovirus infected Sf9 cells
• Poziom jakości: 200
• linia produktu: PRECISIO^® Kinase
• Próba: ≥70% (SDS-PAGE)
• Postać: buffered aqueous glycerol solution
• aktywność właściwa: 12-16 nmol/min·mg
• masa cząsteczkowa: CDK4 subunit ~57 kDa; cyclin D1 ~61 kDa
• numer dostępu UniProt: P11802; P24385
• Warunki transportu: dry ice
• temp. przechowywania: −70°C
• informacje o genach: human ... CCND1(595) , CDK4(1019)

Opis

Działania biochem./fizjol.

CDK4 is a member of the cyclin-dependent protein kinase family and is involved in the control of cell proliferation during the G1 phase of cell cycle. CDK4 forms a complex with the D-type cyclins and is inhibited by p16 (cyclin-dependent kinase inhibitor-2). CDK4 can mediate phosphorylation of the C-terminal region of RB protein leading to an active transcriptional repression of E2F complex.CDC37 and HSP90 can preferentially associate with the fraction of CDK4 not bound to D-type cyclins. SMAD3 is a major physiologic substrate of the G1 cyclin-dependent kinases CDK4 and CDK2.

Postać fizyczna

Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.

Informacje prawne

PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 10 - Combustible liquids
• Klasa zagrożenia wodnego (WGK): WGK 1
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• Środki ochrony indywidualnej: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)