ABS549

Anti-MuSK Antibody

serum, from rabbit

• Synonim(y): Muscle, skeletal receptor tyrosine-protein kinase, Muscle-specific tyrosine-protein kinase receptor, MuSK, Muscle-specific kinase receptor
• Kod UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Właściwości

• pochodzenie biologiczne: rabbit
• Poziom jakości: 100
• forma przeciwciała: serum
• rodzaj przeciwciała: primary antibodies
• klon: polyclonal
• reaktywność gatunkowa: mouse, human
• metody: immunohistochemistry: suitable; immunoprecipitation (IP): suitable; western blot: suitable
• numer dostępu NCBI: NP_001159752
• numer dostępu UniProt: Q61006
• Warunki transportu: wet ice
• docelowa modyfikacja potranslacyjna: unmodified
• informacje o genach: human ... MUSK(4593)

Opis

Opis ogólny

MuSK, also known as Muscle, skeletal receptor tyrosine-protein kinase, Muscle-specific tyrosine-protein kinase receptor, or Muscle-specific kinase receptor, and encoded by the gene MUSK, a key muscle specific receptor tyrosine kinase that plays a central role in the formation and maintenance of the neuromuscular junction (NMJ). The NMJ is the special synapse between the motor neuron and the skeletal muscle. MuSK activation in the myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in the subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors in the postsynaptic membrane. MuSK also plays a role in the CNS by mediating cholinergic responses, synaptic plasticity and memory function. MuSK is a membrane bound protein localized to the postsynaptic side of the cell membrane at the neuromuscular junction in muscle cells.

Immunogen

Epitope: Extracellular domain

Recombinant protein corresponding to the extracellular domain of mouse MuSK.

Zastosowanie

Anti-MuSK antibody is an antibody against MuSK for use in western blotting, IHC & IP.

Research Category
Signaling

Research Sub Category
Signaling Neuroscience

Western Blotting Analysis: A representative lot detected MuSK in C2C12 cell lysate (Simeone, L., et al. (2010). The Journal of Neuro. 30(19):6620-6634).
Immunohistochemistry Analysis: A representative lot detected MuSK in mouse soleus muscle tissue (Simeone, L., et al. (2010). The Journal of Neuro. 30(19):6620-6634).
Immunoprecipitation Analysis: A representative lot immunoprecipitated MuSK in C2C12 cell lysate (Simeone, L., et al. (2010). The Journal of Neuro. 30(19):6620-6634).

Jakość

Evaluated by Western Blotting in HEK293 cell lysate.

Western Blotting Analysis: A 1:1,000 dilution of this antibody detected MuSK in 10 µg of HEK293 cell lysate.

Opis wartości docelowych

~110 kDa observed. Uncharacterized band(s) may appear in some lysates.

Postać fizyczna

Rabbit polyclonal serum with 0.05% sodium azide.

Unpurified

Przechowywanie i stabilność

Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

Oświadczenie o zrzeczeniu się odpowiedzialności

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Ta strona może zawierać tekst przetłumaczony maszynowo.

Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 12 - Non Combustible Liquids
• Klasa zagrożenia wodnego (WGK): WGK 1
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable