V0389

Anti-VGLUT1 antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

• Synonym(s): Anti-BNPI, Anti-Brain-specific Na(+)-dependent inorganic phosphate cotransporter, Anti-Vesicular Glutamate Transporter 1
• MDL number: MFCD03792071
• UNSPSC Code: 12352203
• NACRES: NA.46

Properties

• biological source: rabbit
• conjugate: unconjugated
• antibody form: IgG fraction of antiserum
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen 60 kDa
• species reactivity: human
• technique(s): microarray: suitable; western blot (chemiluminescent): 1:1,000 using synaptic vesicle (SV) fraction of rat brain.
• UniProt accession no.: Q9P2U7
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... SLC17A7(57030)

Description

General description

VGLUT1 (vesicular glutamate transporter 1, originally termed BNPI and characterized as a Na⁺/Pi transporter) is a 60 kDa protein. VGLUT2 is enriched in synaptic vesicles and selective for a distinct class of glutaminergic nerve terminals.

Vesicular glutamate transporter 1 (VGLUT1), also called as solute carrier family 17 member 7 (SLC17A7), is encoded by the gene mapped to human chromosome 19q13, a region associated with schizophrenia. VGLUT1 is specifically expressed in neuronal cells in the brain and at higher levels in neuron-enriched regions such as the amygdala and hippocampus. Glia-enriched areas such as the corpus callosum also show moderate level of expression and substantia nigra, subthalamic nuclei and thalamus show low level expression. VGLUT1 is characterized with a conserved C-terminal dileucine-like motif and two polyproline domains distal to C- terminal end, including one that binds to endocytic BAR (Bin/Amphiphysin/Rvs) domain protein, endophilin.

Immunogen

synthetic peptide corresponding to a region near the C-terminus of human VGLUT1 (amino aicds 504-520).

Biochem/physiol Actions

Vesicular glutamate transporter 1 (VGLUT1) is associated with neuronal pathways that exhibit activity-dependent potentiation, whereas VGLUT2 is expressed in sensory and autonomic pathways that display high fidelity neurotransmission.

Vesicular glutamate transporter 1 (VGLUT1) plays a vital role as a vesicular glutamate transporter in glutamatergic neurons. VGLUT1 expression in the prefrontal cortex functions as a potential neurochemical marker of dementia in Alzheimer′s disease (AD) and antidepressant activity.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 10 - Combustible liquids