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About This Item
Empirical Formula (Hill Notation):
C14H21N5
CAS Number:
Molecular Weight:
259.35
UNSPSC Code:
12352200
NACRES:
NA.77
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Quality Level
Assay
≥98% (HPLC)
form
(Powder or Lyophilized powder or film or oil)
color
colorless to brown-yellow
storage temp.
2-8°C
SMILES string
CCCC1=NC2=CC=NN2C(N[C@H]3C[C@@H](CC3)N)=C1
Biochem/physiol Actions
KI-ARv-03 is a cell penetrant, potent and selective inhibitor of CDK9 that that reduces AR-driven transcription and proliferation in prostate cancer cells. KI-ARv-03 modulates AR and AR-V7-dependent transcription in 22Rv1 cells. It exhibits potent anti-tumor activity in castration-resistant prostate cancer (CRPC) models.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Modulating Androgen Receptor-Driven Transcription in Prostate Cancer with Selective CDK9 Inhibitors.
André Richters et al.
Cell chemical biology, 28(2), 134-147 (2020-10-22)
Castration-resistant prostate cancers (CRPCs) lose sensitivity to androgen-deprivation therapies but frequently remain dependent on oncogenic transcription driven by the androgen receptor (AR) and its splice variants. To discover modulators of AR-variant activity, we used a lysate-based small-molecule microarray assay and
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