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SAB4504670

Sigma-Aldrich

Anti-phospho-FRS2 (pTyr436) antibody produced in rabbit

affinity isolated antibody

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 57 kDa

species reactivity

rat, mouse, human

concentration

~1 mg/mL

technique(s)

ELISA: 1:10000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

NCBI accession no.

Q8WU20

UniProt accession no.

Q8WU20

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

phosphorylation (pTyr436)

Gene Information

human ... FRS2(10818)

General description

Fibroblast growth factor (FGF) receptor substrate 2 (FRS2) is an FGF receptor (FGFR)-associated protein. It is a membrane-bound adaptor protein, that is located on human chromosome 12q15.

Immunogen

The antiserum was produced against synthesized peptide derived from human FRS2 around the phosphorylation site of Tyr436.

Immunogen Range: 402-451

Biochem/physiol Actions

Fibroblast growth factor (FGF) receptor substrate 2 (FRS2) is essential for activation of downstream signaling molecules that are involved in the MAP (‎mitogen-activated protein kinase) and AKT (protein kinase B) kinase pathways. This protein plays an important role in epidermal growth factor (EGF) signaling. It also plays a major role in cell transformation and resistance to therapy. FRS2 helps to link FGF, nerve growth factor (NGF) and glial cell-derived neurotrophic factor (GDNF) receptors with the Ras/mitogen-activated protein (MAP) kinase signaling cascade.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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EGFR and FGFR signaling through FRS2 is subject to negative feedback control by ERK1/2
Wu Y, et al.
Biological Chemistry, 384(8), 1215-1226 (2003)
Hyperactivated FRS2?-mediated signaling in prostate cancer cells promotes tumor angiogenesis and predicts poor clinical outcome of patients
Liu J, et al.
Oncogene, 35(14), 1750-1759 (2016)
Leo Y Luo et al.
Molecular cancer research : MCR, 13(3), 502-509 (2014-11-05)
High-grade serous ovarian cancers (HGSOC) are characterized by widespread recurrent regions of copy-number gain and loss. Here, we interrogated 50 genes that are recurrently amplified in HGSOC and essential for cancer proliferation and survival in ovarian cancer cell lines. FRS2

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