P5248
Etidronate disodium hydrate
≥97% (NMR), solid
Synonym(s):
Dihydrogen (1-hydroxyethylidene)bisphosphonate disodium hydrate
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About This Item
Empirical Formula (Hill Notation):
C2H6Na2O7P2 · xH2O
CAS Number:
Molecular Weight:
249.99 (anhydrous basis)
EC Number:
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
Recommended Products
Quality Level
Assay
≥97% (NMR)
form
solid
color
white
mp
>300 °C
solubility
H2O: ≥10 mg/mL
storage temp.
2-8°C
SMILES string
[Na+].[Na+].CC(O)(P(O)([O-])=O)P(O)([O-])=O
InChI
1S/C2H8O7P2.2Na/c1-2(3,10(4,5)6)11(7,8)9;;/h3H,1H3,(H2,4,5,6)(H2,7,8,9);;/q;2*+1/p-2
InChI key
GWBBVOVXJZATQQ-UHFFFAOYSA-L
Application
Etidronate disodium hydrate has been used in the synthesis of bisphosphonate derivatives of adenosine triphosphate (ATP)by T4 RNA ligase. It has also been sued to inhibit human farnesyl diphosphate synthase (FDPS).
Biochem/physiol Actions
Etidronate helps to guard chronic ocular hypertension prompted retinal oxidative stress. It stimulates the development of retinal ganglion cells through insulin-like growth factor 1 (IGF-1) signaling pathway. It may possess neuroprotective effects in in vivo and in vitro rat model of glaucoma. Etidronate belongs to bisphosphonates.
Bisphosphonate antiresorptive agent. Less potent inhibitor of farnesyl diphosphate synthase (IC50 = 80 μM) as compared to the nitrogen containing bisphosphonates
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral
Storage Class Code
11 - Combustible Solids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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