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Key Documents

LO4200

Sigma-Aldrich

LOPAC®1280 - Small Scale

International Version

Synonym(s):

Library of Pharmacologically Active Compounds - small scale

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About This Item

EC Number:
200-664-3
UNSPSC Code:
12352200
NACRES:
NA.77

form

liquid

shipped in

dry ice

storage temp.

−20°C

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General description

Compounds are arranged in 96-well format in 16 racks of 80, one compound per well (25 μl at 10 mM in DMSO in archival storage racks).

Application

Library of pharmacologically active compounds LOPAC®1280 - small scale has been used to screen for the suppressors of niclosamide- and nigericin-induced interleukin (IL-1β) release.

Features and Benefits

Includes the latest, drug-like molecules in the fields of Cell Signaling & Neuroscience:

  • Apoptosis
  • G Proteins & Cyclic Nucleotides
  • Gene Regulation & Expression
  • Ion Channels
  • Lipid Signaling
  • Multi-Drug Resistance
  • Neurotransmission
  • Phosphorylation
SDFile provided to construct a database containing:
  • Structure
  • Primary Name
  • Secondary Name
  • Pharmacological Activity
  • Product Number
  • Rack Position

Other Notes

For sale outside of the U.S. only. U.S. customers should refer to Product Code LO4100.

Legal Information

LOPAC is a registered trademark of Merck KGaA, Darmstadt, Germany

Signal Word

Danger

Hazard Classifications

Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1A - Eye Dam. 1 - Lact. - Muta. 1B - Repr. 1A - Resp. Sens. 1 - Skin Corr. 1B - Skin Sens. 1 - STOT RE 2 - STOT SE 2

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Flash Point(F)

188.6 °F

Flash Point(C)

87 °C

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

EU REACH Annex XVII (Restriction List)

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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High-throughput screening identifies compounds that enhance lentiviral transduction.
Johnston JM, Denning G, Moot R, et al.
Gene Therapy, doi:10-doi:10 (2014)
Laura M Alcântara et al.
Molecules (Basel, Switzerland), 25(11) (2020-06-04)
High genetic and phenotypic variability between Leishmania species and strains within species make the development of broad-spectrum antileishmanial drugs challenging. Thus, screening panels consisting of several diverse Leishmania species can be useful in enabling compound prioritization based on their spectrum
Kurumi Y Horiuchi et al.
Assay and drug development technologies, 11(4), 227-236 (2013-04-06)
Epigenetic modifications play a crucial role in human diseases. Unlike genetic mutations, however, they do not change the underlying DNA sequences. Epigenetic phenomena have gained increased attention in the field of cancer research, with many studies indicating that they are
James Robinson et al.
Assay and drug development technologies, 11(8), 468-477 (2013-10-15)
The galanin 3 receptor (GalR3) belongs to the large G protein-coupled receptor (GPCR) family of proteins. GalR3 and two other closely related receptors, GalR1 and GalR2, together with their endogenous ligand galanin, are involved in a variety of physiological and
John S Lazo et al.
Molecular pharmacology, 72(1), 1-7 (2007-04-05)
Small molecules are powerful pharmacological tools to dissect biological events. There is now considerable interest in expanding efforts to identify and use small molecules targeting proteins encoded in the genomes of humans and pathogenic organisms. Integration of the principles of
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