I6504

(−)-Isoproterenol hydrochloride

≥98% (TLC), powder, β-adrenoceptor agonist

• Synonym(s): (−)-Isoprenaline hydrochloride, (−)-N-Isopropyl-L-noradrenaline hydrochloride, (R)-3,4-Dihydroxy-α-(isopropylaminomethyl)benzyl alcohol hydrochloride
• Linear Formula: 3,4-(HO)₂C₆H₃CH(OH)CH₂NHCH(CH₃)₂·HCl
• CAS Number: 5984-95-2
• Molecular Weight: 247.72
• Beilstein: 6077193
• MDL number: MFCD00064548
• UNSPSC Code: 12352200
• PubChem Substance ID: 24278495
• NACRES: NA.77

Properties

• product name: (−)-Isoproterenol hydrochloride,
• Quality Level: 200
• mp: 175 °C (dec.) (lit.)
• solubility: soluble (50 mg/ml: H₂O)
• storage temp.: −20°C
• SMILES string: Cl[H].CC(C)NC[C@H](O)c1ccc(O)c(O)c1
• InChI: 1S/C11H17NO3.ClH/c1-7(2)12-6-11(15)8-3-4-9(13)10(14)5-8;/h3-5,7,11-15H,6H2,1-2H3;1H/t11-;/m0./s1
• InChI key: IROWCYIEJAOFOW-MERQFXBCSA-N
• Gene Information: human ... ADRB2(154)

Description

Application

(−)-Isoproterenol hydrochloride has been used in in vitro explant culture. It has also been used in transcriptome analysis of heart.

Biochem/physiol Actions

Isoproterenol hydrochloride is useful in post transplantal organ recovery. It exhibits ionotropic and chronotropic effects. With respect to donor heart recovery, isoproterenol hydrochloride decreases peripheral and systemic vascular resistance. Isoproterenol also increases the heart rate.

β-adrenoceptor agonist; increases cytosolic cAMP.

Preparation Note

This material can be dissolved in 50 mg/ml of H₂O.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H315,H319,H335
• Precautionary Statements: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves