G8044
Anti-phospho-GATA4 (pSer105) antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
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About This Item
conjugate:
unconjugated
application:
WB
clone:
polyclonal
species reactivity:
mouse
citations:
2
technique(s):
western blot: 1:500
Recommended Products
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 46 kDa
species reactivity
mouse
packaging
pkg of (1 vl = 100ul)
technique(s)
western blot: 1:500
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... GATA4(2626)
mouse ... Gata4(14463)
rat ... Gata4(54254)
Related Categories
Immunogen
Anti-phospho-GATA4 (pSer105) antibody produced in rabbit is suitable for western blotting at working dilution 1:500.
synthetic phosphopeptide derived from the region of GATA-4 that contains serine 105.
Biochem/physiol Actions
GATA-4 has a molar mass of 46kDa and belongs to the GATA family of zinc finger-containing transcription factors. It is involved in the development of cardiac hypertrophy and remodeling. It plays a crucial role in regulating basal and agonist or stress-induced gene expression in cardiac and smooth muscle cell types. Upon agonist stimulation via MEK1-ERK1/2, and weakly via JNK or p38 MAPKs, Ser105 of GATA-4 is phosphorylated. Phosphorylation of GATA-4 by hepatocyte growth factor facilitates cell survival in cardiac muscle cells via MEK/ERK-dependent signaling pathway.
Physical form
Solution in Dulbecco′s PBS, pH 7.3 with 1 mg/mL BSA and 0.05% Sodium Azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
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Kazumi Kitta et al.
The Journal of biological chemistry, 278(7), 4705-4712 (2002-12-07)
Hepatocyte growth factor (HGF) is released in response to myocardial infarction and may play a role in regulating cardiac remodeling. Recently, HGF was found to inhibit the apoptosis of cardiac muscle cells. Because GATA-4 can induce cell survival, the effects
Q Liang et al.
Molecular and cellular biology, 21(21), 7460-7469 (2001-10-05)
The zinc finger-containing transcription factor GATA4 has been implicated as a critical regulator of multiple cardiac-expressed genes as well as a regulator of inducible gene expression in response to hypertrophic stimulation. Here we demonstrate that GATA4 is itself regulated by
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