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F1553

Sigma-Aldrich

S-(+)-Fluoxetine hydrochloride

≥98% (HPLC), solid

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About This Item

Empirical Formula (Hill Notation):
C17H18NOF3 · HCl
CAS Number:
114247-06-2
Molecular Weight:
345.79
MDL number:
MFCD04040001
UNSPSC Code:
12352200
PubChem Substance ID:
24278432
NACRES:
NA.77

Assay

≥98% (HPLC)

form

solid

optical activity

[α]/D +14 to +19°, c = 1 in chloroform-d

storage condition

desiccated

color

white

solubility

H2O: soluble ≥20 mg/mL

originator

Eli Lilly

storage temp.

room temp

SMILES string

Cl.CNCC[C@H](Oc1ccc(cc1)C(F)(F)F)c2ccccc2

InChI

1S/C17H18F3NO.ClH/c1-21-12-11-16(13-5-3-2-4-6-13)22-15-9-7-14(8-10-15)17(18,19)20;/h2-10,16,21H,11-12H2,1H3;1H/t16-;/m0./s1

InChI key

GIYXAJPCNFJEHY-NTISSMGPSA-N

Gene Information

human ... HTR1A(3350) , HTR1B(3351) , HTR1D(3352) , HTR1E(3354) , HTR1F(3355) , HTR2A(3356) , HTR2B(3357) , HTR2C(3358) , HTR3A(3359) , HTR3B(9177) , HTR3C(170572) , HTR3D(200909) , HTR3E(285242) , HTR4(3360) , HTR5A(3361) , HTR5B(645694) , HTR6(3362) , HTR7(3363)

General description

Fluoxetine hydrochloride or fluoxetine hcl is a psychotropic agent and one of the initial members of the anti-depressant class of drugs known as selective serotonin-reuptake inhibitors (SSRIs). It is the active ingredient of Prozac®.

Biochem/physiol Actions

Fluoxetine hcl (hydrochloride) is a selective serotonin reuptake inhibitor and functions as an antidepressant. This drug works at presynaptic terminals where it prevents the reuptake of serotonin, resulting in the accumulation of serotonin in extracellular fluid at synapses.
Selective serotonin reuptake inhibitor.

Features and Benefits

This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

Prozac is a registered trademark of Eli Lilly and Co.

Pictograms

Exclamation markEnvironment
GHS07,GHS09

Signal Word

Warning

Hazard Statements

H302,H410

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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David T Wong et al.
Nature reviews. Drug discovery, 4(9), 764-774 (2005-08-27)
In the early 1970s, evidence of the role of serotonin (5-hydroxytryptamine or 5-HT) in depression began to emerge and the hypothesis that enhancing 5-HT neurotransmission would be a viable mechanism to mediate antidepressant response was put forward. On the basis
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The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways that governs the

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