C1145
Cholesterol–PEG 600
Synonym(s):
Cholesterol, water soluble from sheep, Cholesteryl-polyethylene glycol 600 sebacate, Polyethylene glycol 600 mono(cholesteryl) ether sebacate, Polyoxyethyl-cholesteryl sebacate
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About This Item
Recommended Products
form
solid
extent of labeling
≥20% cholesterol
color
light yellow
solubility
H2O: 60 mg/mL
shipped in
dry ice
storage temp.
−20°C
General description
Cholesterol is one of the important constituent of all membranes. It is made up of a hydrophobic, planar, a polar hydroxyl group, fused-ring nucleus and a short hydrocarbon tail.
Application
Cholesterol-PEG 600 has been used to evaluate its ability to induce apoptosis in vascular smooth muscle cells. It has also been used to restore cholesterol following depletion by methyl β-cyclodextrin.
Biochem/physiol Actions
Cholesterol acts as an antecedent of steroid hormones. It plays a key role in fetal growth and in brain development.
Physical form
semisolid to solid
Preparation Note
Prepared by method of Proksch, G.J., and Bonderman, D.P., Clin. Chem., 24, 1924 (1978).
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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Apoptosis of vascular smooth muscle cells induced by cholesterol and its oxides in vitro and in vivo
Yin J, et al.
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M Absi et al.
British journal of pharmacology, 151(3), 332-340 (2007-04-24)
The small and intermediate conductance, Ca2+-sensitive K+ channels (SK(Ca) and IK(Ca), respectively) which are pivotal in the EDHF pathway may be differentially activated. The importance of caveolae in the functioning of IK(Ca) and SK(Ca) channels was investigated. The effect of
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