C5548

Clobetasone butyrate

≥98%

• Synonym(s): 21-Chloro-9-fluoro-17-hydroxy-16-methylpregna-1,4-diene-3,11,20-trione 17-butyrate
• Empirical Formula (Hill Notation): C₂₆H₃₂ClFO₅
• CAS Number: 25122-57-0
• Molecular Weight: 478.98
• EC Number: 246-635-9
• MDL number: MFCD00133196
• UNSPSC Code: 12171500
• PubChem Substance ID: 329775093
• NACRES: NA.47

Properties

• Quality Level: 200
• Assay: ≥98%
• form: powder
• color: white to faint yellow cast
• mp: 90-100 °C
• solubility: chloroform: 50 mg/mL, clear, faintly yellow
• ε (extinction coefficient): 13.4 at 243 nm in chloroform
• application(s): diagnostic assay manufacturing; hematology; histology
• storage temp.: room temp
• SMILES string: CCCC(=O)O[C@@]1([C@@H](C)C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)C(=O)C[C@]12C)C(=O)CCl
• InChI: 1S/C26H32ClFO5/c1-5-6-22(32)33-26(21(31)14-27)15(2)11-19-18-8-7-16-12-17(29)9-10-23(16,3)25(18,28)20(30)13-24(19,26)4/h9-10,12,15,18-19H,5-8,11,13-14H2,1-4H3/t15-,18-,19-,23-,24-,25-,26-/m0/s1
• InChI key: FBRAWBYQGRLCEK-AVVSTMBFSA-N

Description

General description

Clobetasone butyrate is a corticosteroid.

Application

Clobetasone butyrate has been used as an internal standard for the quantitative assay of clobetasol propionate.

Clobetasone butyrate has been used to analyze its bio-concentration factor (BCF) in Cyprinus carpio.

Biochem/physiol Actions

Clobetasone butyrate is a potent topical corticosteroid and is primarily used to treat atopic dermatitis (AD). Low dosage of this drug is used to treat dry eye in Sjogrens syndrome.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves