48912-U
ProClin™ 300
pkg of 50 mL, ProClin™ preservative for use in IVD manufacturing, CMIT/MIT 3 %
Synonym(s):
3% solution of 5-chloro-2-methyl-4-isothiazolin-3-one and 2-Methyl-4-isothiazolin-3-one
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About This Item
UNSPSC Code:
12352201
NACRES:
NA.21
Recommended Products
Quality Level
form
liquid
shelf life
3 yr
contains
Alkyl Carboxylate
composition
CMIT/MIT, 3%
packaging
pkg of 50 mL
parameter
<45 °C operating temperature
color
colorless to light yellow
matrix
Modified glycol
operating pH range
2.5-8.5
pH
4.1 (100 g/L)
bp
189 °C
mp
-40 °C
solubility
water: soluble
density
1.03 g/cm3
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General description
ProClin™ preservatives are water-soluble preparations of biocides that are generally used to increase the shelf life of reagents. ProClin™ 300 comprises of 3% of 5-chloro-2-methyl-4-isothiazolin-3-one (CMIT) and 2-methyl-4-isothiazloin-3-one (MIT) in a salt-free proprietary glycol containing an alkly carboxylate stabilizer. It has a recommended working pH range as 2.5 - 8.5.
Application
For use in biological diagnostic assays and IVDs only
ProClin biocides are immediately microstatic upon contact with microbial organisms as a result of their ability to quickly penetrate cell membranes and inhibit specific enzymes crucial to cellular respiration. Multiple specific sites of ProClin toxicity prevent microorganisms from developing high levels of resistance, making ProClin highly efficient even over extended storage periods of your IVD components.
ProClin™ 300 is suitable for preparation of different buffers like ELISA buffer, sample and substrate dilution buffers for Single-Molecule Arrays (Simoa assay) and Immunoenzymatic assay. Additionally, Proclin™ may be used in preparing storage buffer to store beads coupled with coronavirus nucleocapsid protein for the serological multiplex assay.
Biochem/physiol Actions
ProClin™ products contain active substances like CMIT and MIT which inhibit the Krebs cycle at four different check points, the enzymes pyruvate dehydrogenase, α-ketoglutarate dehydrogenase, succinate dehydrogenase, and NADH dehydrogenase. The inhibition of Krebs cycle leads to effective broad-spectrum biocidal activity against bacteria, fungi, and yeast.
Legal Information
ProClin is a trademark of LANXESS Corp.
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Corr. 1B - Skin Sens. 1
Storage Class Code
8A - Combustible, corrosive hazardous materials
WGK
WGK 3
Flash Point(F)
244.4 °F - closed cup
Flash Point(C)
118 °C - closed cup
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Annika Nelde et al.
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GI Khvatova and AV Semeikin
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Cohen L, et al.
Journal of Immunological Methods, 452, 20-25 (2018)
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James P Higham et al.
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