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Key Documents

MAB5598

Sigma-Aldrich

Anti-HCN3 Antibody, clone TLL 6C5

culture supernatant, clone TLL 6C5, Chemicon®

Synonym(s):

Hyperpolarization-activated and cyclic nucleotide-gated channel 3

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rat

Quality Level

100

antibody form

culture supernatant

antibody product type

primary antibodies

clone

TLL 6C5, monoclonal

species reactivity

mouse, rat

manufacturer/tradename

Chemicon®

technique(s)

immunohistochemistry: suitable
western blot: suitable

isotype

IgG1

NCBI accession no.

NM_020897.1

UniProt accession no.

Q9P1Z3

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

mouse ... Hcn3(15168)

Specificity

HCN3 (Hyperpolarization-activated and cyclic nucleotide-gated channel 3). The antibody recognizes both the glycosyated and deglycosylated form of HCN3. The antibody recognizes a band at ~90 kDa in glycosylated protein from a retinal membrane preparation.

Immunogen

Synthetic peptide from rat HCN3.

Application

Anti-HCN3 Antibody, clone TLL 6C5 detects level of HCN3 & has been published & validated for use in IH & WB.
Western blot on rat and mouse retina. The antibody recognizes a band at ~90 kDa in glycosylated protein from a retinal membrane preparation.

Immunohistochemistry on rat and mouse retina.

Optimal working dilutions must be determined by end user.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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An essential role for modulation of hyperpolarization-activated current in the development of binaural temporal precision.
Khurana, S; Liu, Z; Lewis, AS; Rosa, K; Chetkovich, D; Golding, NL
The Journal of Neuroscience null
Frank Müller et al.
The European journal of neuroscience, 17(10), 2084-2096 (2003-06-06)
Hyperpolarization-activated and cyclic nucleotide-gated (HCN) channels codetermine the integrative behaviour of neurons and shape their response to synaptic stimulation. We used immunohistochemistry and patch-clamp recording to study the composition and distribution of HCN channels in the rat retina. All four

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