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MAB344

Sigma-Aldrich

Anti-O1 Antibody, clone 59

clone 59, Chemicon®, from mouse

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

Quality Level

100

antibody form

saturated ammonium sulfate (SAS) precipitated

clone

59, monoclonal

species reactivity

chicken, rat, mouse, human

manufacturer/tradename

Chemicon®

technique(s)

immunohistochemistry: suitable

isotype

IgM

shipped in

wet ice

target post-translational modification

unmodified

Specificity

Recognizes Oligodendrocyte marker O1. Also reacts with certain galactolipids in sperm (see Additional Information library for list).

Immunogen

White matter of corpus callosum from rat brain.

Application

Anti-O1 Antibody, clone 59 is an antibody against O1 for use in IH.
Immunohistochemistry: 10-20 μg/mL on unfixed, shock frozen tissue.

Note: 01 is a lipid which is released from the membrane by alcohol.

Optimal working dilutions must be determined by the end user.
Research Category
Neuroscience
Research Sub Category
Neuronal & Glial Markers

Physical form

Format: Purified
Liquid. Buffer = 0.05 M Potassium Phosphate, 0.3 M NaCl, pH 8.0 with 0.05% sodium azide.

Storage and Stability

Maintain lyophilized material at +2–8°C for up to 12 months. After reconstitution maintain frozen at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.

Analysis Note

Control
Oligodendrocyte culture, Brain

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Jong-Wan Kim et al.
Folia neuropathologica, 57(1), 24-35 (2019-05-01)
This study was performed to determine whether the disturbed maturation of oligodendrocyte (OL) progenitors might be related to lipopolysaccharide (LPS)-induced hypomyelination. We created organotypic cultures of forebrain slices from neonatal rats and explored the morphological changes of glial cells expressing
Olfactory ensheathing cells exhibit unique migratory, phagocytic, and myelinating properties in the X-irradiated spinal cord not shared by Schwann cells.
Karen L Lankford,Masanori Sasaki,Christine Radtke,Jeffery D Kocsis
Glia null
Developmental expression in central and peripheral nervous system of oligodendrocyte cell surface antigens (O antigens) recognized by monoclonal antibodies.
M Schachner et al.
Developmental biology, 83(2), 328-338 (1981-04-30)
Administration of dexamethasone to neonatal rats induces hypomyelination and changes in the morphology of oligodendrocyte precursors.
Kim, JW; Kim, YJ; Chang, YP
Comparative Medicine null
Zhong Liu et al.
Stem cells and development, 26(3), 177-188 (2016-10-21)
Neural stem cells (NSCs) have the capacity to differentiate into neurons, astrocytes, and oligodendrocytes, and therefore represent a promising donor tissue source for treating neurodegenerative diseases and repairing injuries of the nervous system. However, it remains unclear how canonical microRNAs
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