Quality Level
product line
NovaSyn® TG
Novabiochem®
form
beads
reaction suitability
reaction type: Fmoc solid-phase peptide synthesis
manufacturer/tradename
Novabiochem®
application(s)
peptide synthesis
functional group
alcohol
storage temp.
2-30°C
General description
NovaSynTG hydroxy resin is a composite of low cross-linked polystyrene and 3000-4000 M.W. polyethylene glycol, in which the ends of the PEG chains have been functionalized with hydroxyl groups. The 130 μm beads have a narrow size distribution, high diffusion rates and excellent swelling across a wide range of solvents from toluene to water [1,2,3], making them ideally suited to the synthesis of serial and parallel libraries by organic solid phase synthesis. This support has been used for the solid phase immobilization of carboxylic acids [4,5,6,7,8,9], with cleavage by saponification with dilute aq. NaOH.
Associated Protocols and Technical Articles
Protocols for Loading of Peptide Synthesis Resins
Literature references
[1] W. Rapp, et al. in ′Innovation & Perspectives in Solid Phase Synthesis, 1st International Symposium′, R. Epton (Eds), SPCC UK Ltd., Birmingham, 1990, pp. 205.
[2] L. Zhang, et al. in ′Peptides 1990, Proc. 21st European Peptide Symposium′, E. Giralt & D. Andreu (Eds), ESCOM, Leiden, 1990, pp.196.
[3] E. Bayer (1991) Angew. Chem. Int. Ed. Engl., 30, 113.
[4] M. Hiroshige, et al. (1995) Tetrahedron Lett., 36, 4567.
[5] M. C. Fagnola, et al. (1997) Tetrahedron Lett., 38, 2307.
[6] D. Fancelli, et al. (1997) Tetrahedron Lett., 38, 2311.
[7] M. Patek, et al. (1995) Tetrahedron Lett., 36, 2227.
[8] V. Krchnak, et al. (1995) Tetrahedron Lett., 36, 6193.
[9] A. K. Szardenings & T. S. Burkoth (1997)Tetrahedron, 53, 6573.
Associated Protocols and Technical Articles
Protocols for Loading of Peptide Synthesis Resins
Literature references
[1] W. Rapp, et al. in ′Innovation & Perspectives in Solid Phase Synthesis, 1st International Symposium′, R. Epton (Eds), SPCC UK Ltd., Birmingham, 1990, pp. 205.
[2] L. Zhang, et al. in ′Peptides 1990, Proc. 21st European Peptide Symposium′, E. Giralt & D. Andreu (Eds), ESCOM, Leiden, 1990, pp.196.
[3] E. Bayer (1991) Angew. Chem. Int. Ed. Engl., 30, 113.
[4] M. Hiroshige, et al. (1995) Tetrahedron Lett., 36, 4567.
[5] M. C. Fagnola, et al. (1997) Tetrahedron Lett., 38, 2307.
[6] D. Fancelli, et al. (1997) Tetrahedron Lett., 38, 2311.
[7] M. Patek, et al. (1995) Tetrahedron Lett., 36, 2227.
[8] V. Krchnak, et al. (1995) Tetrahedron Lett., 36, 6193.
[9] A. K. Szardenings & T. S. Burkoth (1997)Tetrahedron, 53, 6573.
Linkage
Replaces: 01-64-0096
Analysis Note
Color (visual): white to amber to beige
Appearance of substance (visual): beads
Loading (determined from the substitution of the Fmoc-Leu loaded resin): 0.20 - 0.30 mmol/g
Swelling Volume (in CH₂Cl₂): lot specific result
130 µm beads
Appearance of substance (visual): beads
Loading (determined from the substitution of the Fmoc-Leu loaded resin): 0.20 - 0.30 mmol/g
Swelling Volume (in CH₂Cl₂): lot specific result
130 µm beads
Legal Information
NOVASYN is a registered trademark of Merck KGaA, Darmstadt, Germany
Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
11 - Combustible Solids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service