8.22322

Phosphorus trichloride

for synthesis

• Synonym(s): Phosphorus trichloride, Phosphorus(III) chloride, Phosphorus chloride
• CAS Number: 7719-12-2
• Molecular Weight: 137.33
• MDL number: MFCD00011438
• UNSPSC Code: 12352302
• EC Index Number: 231-749-3
• NACRES: NA.22

Properties

• vapor pressure: 131 hPa ( 20 °C)
• Quality Level: 200
• Assay: ≥99% (argentometric)
• form: liquid
• potency: 18 mg/kg LD₅₀, oral (Rat)
• pH: 1 (20 °C, 5 g/L in H₂O)
• bp: 76 °C/1013 hPa
• mp: -94 °C
• density: 1.57 g/cm³ at 20 °C
• storage temp.: 2-30°C
• InChI: 1S/Cl3P/c1-4(2)3
• InChI key: FAIAAWCVCHQXDN-UHFFFAOYSA-N

Description

General description

for synthesis

Application

Phosphorus trichloride (PCl₃) can be used as:

• A chlorinating agent for the alcohols, aldehydes, ketones, and carboxylic acids.
• A reagent to convert alcohols, diols, and phenols to phosphites.
• A reducing agent to reduce sulfoxides, amine N-oxides, and hydroxy amides to corresponding sulfides, amines, and amides.

It can also be used as a reagent to synthesize:

• Phosphaindolizines and thiazolodiazaphospholes by reacting with quaternary ammonium salts.
• Phosphorus-containing ligand molecules via the introduction of the phosphorus atom.
• Benzidronate by treating with phenylacetic acid and phosphorous acid in methanesulfonic acid, followed by hydrolysis.

Analysis Note

Assay (argentometric)≥ 99.0 %Density (d 20 °C/ 4 °C)1.572 - 1.574

Safety Information

• Pictograms: GHS05,GHS06,GHS08
• Signal Word: Danger
• Hazard Statements: H300 + H330 - H314 - H373
• Precautionary Statements: P260 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P314
• Hazard Classifications: Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Eye Dam. 1 - Skin Corr. 1A - STOT RE 2 Inhalation
• Target Organs: Respiratory Tract
• Supplementary Hazards: EUH014 - EUH029
• Storage Class Code: 6.1B - Non-combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable