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235135

Sigma-Aldrich

Corticosterone

Corticosteroid hormone synthesized in response to stress.

Synonym(s):

Corticosterone, (11β)-11,21-Dihydroxypregn-4-ene-3,20-dione, Reichstein’s substance H

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About This Item

Empirical Formula (Hill Notation):
C21H30O4
CAS Number:
50-22-6
Molecular Weight:
346.46
MDL number:
MFCD00037715
UNSPSC Code:
12352200

Quality Level

100

Assay

≥95% (HPLC)

form

crystalline powder

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

off-white
 white to tan

solubility

ethanol: 50 mg/mL

shipped in

ambient

storage temp.

10-30°C

InChI

1S/C21H30O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-17,19,22,24H,3-8,10-11H2,1-2H3/t14-,15-,16+,17-,19+,20-,21-/m0/s1

InChI key

OMFXVFTZEKFJBZ-HJTSIMOOSA-N

General description

Corticosteroid hormone synthesized in response to stress. Binds to and activates mineralocorticoid and glucocorticoid receptors, resulting in altered expression which eventually affects ionic conductances through the membrane. Also induces apoptosis in murine bone marrow.
Corticosteroid hormone synthesized in response to stress. Binds to and activates mineralocorticoid and glucocorticoid receptors, resulting in altered genomic expression. Steroid-induced changes in protein synthesis eventually affect ionic conductances through the membrane. Also induces apoptosis in murine bone marrow.

Biochem/physiol Actions

Cell permeable: no
Primary Target
Mineralocorticoid and glucocorticoid receptors
Product does not compete with ATP.
Reversible: no

Warning

Toxicity: Carcinogenic / Teratogenic (D)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Garvy, B.A., et al. 1993. Immunology80, 587.
DeKloet, E.R. 1992. Ann. N.Y. Acad. Sci.663, 357.
Joels, M., and deKloet, E.R. 1992. Trends Neurosci.15, 25.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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