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860841P

Avanti

C18(2S-OH) Galactosyl(β) Ceramide

Avanti Polar Lipids

Synonym(s):

D-galactosyl-β1-1′-N-[2′′(S)-hydroxystearoyl]-D-erythro-sphingosine

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About This Item

Empirical Formula (Hill Notation):
C42H81NO9
CAS Number:
168395-96-8
Molecular Weight:
744.09
UNSPSC Code:
12352211
NACRES:
NA.25

form

powder

packaging

pkg of 1 × 5 mg (860841P-5mg)

manufacturer/tradename

Avanti Polar Lipids

lipid type

sphingolipids

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@](/C=C/CCCCCCCCCCCCC)(O)[C@@]([H])(NC([C@@H](O)CCCCCCCCCCCCCCCC)=O)CO[C@H](O1)[C@H](O)[C@@H](O)[C@H]([C@H]1CO)O

General description

C18(2S-OH) Galactosyl(β) Ceramide, also known as D-galactosyl-β1-1′-N-[2′′(S)-hydroxystearoyl]-D-erythro-sphingosine is a hexosylceramide. Galactosyl(β) Ceramide synthesis is catalyzed by the enzyme β-GalCer synthase (UGT8A).

Biochem/physiol Actions

Galactosyl(β) Ceramide acts as a globotriaosylceramide synthase substrate to produce galabiaosylceramide. Altered levels of this lipid is associated with the development of various diseases including malignancy, sphingolipidosis, diabetes and chronic kidney diseases.

Packaging

5 mL Amber Glass Screw Cap Vial (860841P-5mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

No data available

Flash Point(C)

No data available

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Johanna von Gerichten et al.
Journal of lipid research, 58(6), 1247-1258 (2017-04-05)
Mammals synthesize, cell-type specifically, the diastereomeric hexosylceramides, β-galactosylceramide (GalCer) and β-glucosylceramide (GlcCer), which are involved in several diseases, such as sphingolipidosis, diabetes, chronic kidney diseases, or cancer. In contrast, Bacteroides fragilis, a member of the human gut microbiome, and the

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